Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection
We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absenc...
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| Lenguaje: | inglés |
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2023
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| _version_ | 1881508872870428672 |
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| author | Trupti Gilada Angela K. Ulrich Yixin Wang Javier R. Lama Ricardo Alfaro Socorro Harb Glenda Daza Sarah Holte Siavash Pasalar Jessica Ríos Carmela Ganoza Sayan Dasgupta Robert W. Coombs Ann Duerr |
| author_browse | Angela K. Ulrich Ann Duerr Carmela Ganoza Glenda Daza Javier R. Lama Jessica Ríos Ricardo Alfaro Robert W. Coombs Sarah Holte Sayan Dasgupta Siavash Pasalar Socorro Harb Trupti Gilada Yixin Wang |
| author_facet | Trupti Gilada Angela K. Ulrich Yixin Wang Javier R. Lama Ricardo Alfaro Socorro Harb Glenda Daza Sarah Holte Siavash Pasalar Jessica Ríos Carmela Ganoza Sayan Dasgupta Robert W. Coombs Ann Duerr |
| author_sort | Trupti Gilada |
| collection | Producción científica |
| description | We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2-10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1758 |
| institution | UPeU |
| language | English |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/17582026-10-30T16:16:42ZViral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 InfectionTrupti GiladaAngela K. UlrichYixin WangJavier R. LamaRicardo AlfaroSocorro HarbGlenda DazaSarah HolteSiavash PasalarJessica RíosCarmela GanozaSayan DasguptaRobert W. CoombsAnn DuerrSemenViral loadAntiretroviral therapyHuman immunodeficiency virus (HIV)MedicineVirologyImmunologyBiologyAndrologySemenViral loadAntiretroviral therapyHuman immunodeficiency virus (HIV)MedicineVirologyImmunologyBiologyAndrologyHumansHumansHumansHumansHumansHumansPlasmaPlasmaPlasmaPlasmaPlasmaPlasmaRNA, ViralRNA, ViralRNA, ViralRNA, ViralRNA, ViralRNA, ViralSemenSemenSemenSemenSemenSemenHIV-1HIV-1HIV-1HIV-1HIV-1HIV-1HIV InfectionsHIV InfectionsHIV InfectionsHIV InfectionsHIV InfectionsHIV InfectionsViral LoadViral LoadViral LoadViral LoadViral LoadViral LoadHealth Sciences Medicine Infectious Diseases HIV/AIDS Research and InterventionsLife Sciences Immunology and Microbiology Virology HIV Research and TreatmentHealth Sciences Medicine Emergency Medicine HIV-related health complications and treatmentsWe assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2-10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection.Articlehttps://pubmed.ncbi.nlm.nih.gov/38073467https://pmc.ncbi.nlm.nih.gov/articles/PMC11011176/pdf/jiad520.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/1101117610.1093/infdis/jiad520https://hdl.handle.net/20.500.15037/1758W4389538300enThe Journal of Infectious Diseases0022-18991537-66132023-11-242026-06-13T14:21:37Z2026-06-13T14:21:37Z |
| spellingShingle | Semen Viral load Antiretroviral therapy Human immunodeficiency virus (HIV) Medicine Virology Immunology Biology Andrology Semen Viral load Antiretroviral therapy Human immunodeficiency virus (HIV) Medicine Virology Immunology Biology Andrology Humans Humans Humans Humans Humans Humans Plasma Plasma Plasma Plasma Plasma Plasma RNA, Viral RNA, Viral RNA, Viral RNA, Viral RNA, Viral RNA, Viral Semen Semen Semen Semen Semen Semen HIV-1 HIV-1 HIV-1 HIV-1 HIV-1 HIV-1 HIV Infections HIV Infections HIV Infections HIV Infections HIV Infections HIV Infections Viral Load Viral Load Viral Load Viral Load Viral Load Viral Load Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Life Sciences Immunology and Microbiology Virology HIV Research and Treatment Health Sciences Medicine Emergency Medicine HIV-related health complications and treatments Trupti Gilada Angela K. Ulrich Yixin Wang Javier R. Lama Ricardo Alfaro Socorro Harb Glenda Daza Sarah Holte Siavash Pasalar Jessica Ríos Carmela Ganoza Sayan Dasgupta Robert W. Coombs Ann Duerr Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection |
| title | Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection |
| title_full | Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection |
| title_fullStr | Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection |
| title_full_unstemmed | Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection |
| title_short | Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection |
| title_sort | viral load dynamics in plasma and semen when antiretroviral therapy is initiated during early hiv 1 infection |
| topic | Semen Viral load Antiretroviral therapy Human immunodeficiency virus (HIV) Medicine Virology Immunology Biology Andrology Semen Viral load Antiretroviral therapy Human immunodeficiency virus (HIV) Medicine Virology Immunology Biology Andrology Humans Humans Humans Humans Humans Humans Plasma Plasma Plasma Plasma Plasma Plasma RNA, Viral RNA, Viral RNA, Viral RNA, Viral RNA, Viral RNA, Viral Semen Semen Semen Semen Semen Semen HIV-1 HIV-1 HIV-1 HIV-1 HIV-1 HIV-1 HIV Infections HIV Infections HIV Infections HIV Infections HIV Infections HIV Infections Viral Load Viral Load Viral Load Viral Load Viral Load Viral Load Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Life Sciences Immunology and Microbiology Virology HIV Research and Treatment Health Sciences Medicine Emergency Medicine HIV-related health complications and treatments |
| topic_facet | Semen Viral load Antiretroviral therapy Human immunodeficiency virus (HIV) Medicine Virology Immunology Biology Andrology Semen Viral load Antiretroviral therapy Human immunodeficiency virus (HIV) Medicine Virology Immunology Biology Andrology Humans Humans Humans Humans Humans Humans Plasma Plasma Plasma Plasma Plasma Plasma RNA, Viral RNA, Viral RNA, Viral RNA, Viral RNA, Viral RNA, Viral Semen Semen Semen Semen Semen Semen HIV-1 HIV-1 HIV-1 HIV-1 HIV-1 HIV-1 HIV Infections HIV Infections HIV Infections HIV Infections HIV Infections HIV Infections Viral Load Viral Load Viral Load Viral Load Viral Load Viral Load Health Sciences Medicine Infectious Diseases HIV/AIDS Research and Interventions Life Sciences Immunology and Microbiology Virology HIV Research and Treatment Health Sciences Medicine Emergency Medicine HIV-related health complications and treatments |
| url | https://pubmed.ncbi.nlm.nih.gov/38073467 https://pmc.ncbi.nlm.nih.gov/articles/PMC11011176/pdf/jiad520.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/11011176 https://hdl.handle.net/20.500.15037/1758 |
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