Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019
Although pigs are naturally susceptible to Reston virus and experimentally to Ebola virus (EBOV), their role in Orthoebolavirus ecology remains unknown. We tested 888 serum samples collected from pigs in Guinea during 2017-2019 (between the 2013-16 epidemic and its resurgence in 2021) by indirect EL...
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2024
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| author | Solène Grayo Alimou Camara Bakary Doukouré Isabelle Ellis Cécile Troupin Kerstin Fischer Jessica Vanhomwegen Michaël White Martin H. Groschup Sandra Diederich Noël Tordo |
| author_browse | Alimou Camara Bakary Doukouré Cécile Troupin Isabelle Ellis Jessica Vanhomwegen Kerstin Fischer Martin H. Groschup Michaël White Noël Tordo Sandra Diederich Solène Grayo |
| author_facet | Solène Grayo Alimou Camara Bakary Doukouré Isabelle Ellis Cécile Troupin Kerstin Fischer Jessica Vanhomwegen Michaël White Martin H. Groschup Sandra Diederich Noël Tordo |
| author_sort | Solène Grayo |
| collection | Producción científica |
| description | Although pigs are naturally susceptible to Reston virus and experimentally to Ebola virus (EBOV), their role in Orthoebolavirus ecology remains unknown. We tested 888 serum samples collected from pigs in Guinea during 2017-2019 (between the 2013-16 epidemic and its resurgence in 2021) by indirect ELISA against the EBOV nucleoprotein. We identified 2 hotspots of possible pig exposure by IgG titer levels: the northern coast had 48.7% of positive serum samples (37/76), and Forest Guinea, bordering Sierra Leone and Liberia, where the virus emerged and reemerged, had 50% of positive serum samples (98/196). The multitarget Luminex approach confirms ELISA results against Ebola nucleoprotein and highlights cross-reactivities to glycoprotein of EBOV, Reston virus, and Bundibugyo virus. Those results are consistent with previous observations of the circulation of Orthoebolavirus species in pig farming regions in Sierra Leone and Ghana, suggesting potential risk for Ebola virus disease in humans, especially in Forest Guinea. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1733 |
| institution | UPeU |
| language | English |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/17332026-10-30T16:16:37ZGeographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019Solène GrayoAlimou CamaraBakary DoukouréIsabelle EllisCécile TroupinKerstin FischerJessica VanhomwegenMichaël WhiteMartin H. GroschupSandra DiederichNoël TordoSierra leoneEbola virusVirologyNucleoproteinVirusEbolavirusBiologyPopulationTiterMarburg virusGuinea pigMedicineSocioeconomicsEnvironmental healthEndocrinologySociologySierra leoneEbola virusVirologyNucleoproteinVirusEbolavirusBiologyPopulationTiterMarburg virusGuinea pigMedicineSocioeconomicsEnvironmental healthAnimalsAnimalsAnimalsAnimalsAnimalsAnimalsHumansHumansHumansHumansHumansHumansNucleoproteins geneticsNucleoproteins geneticsNucleoproteins geneticsNucleoproteins geneticsNucleoproteins geneticsNucleoproteins geneticsSierra Leone epidemiologySierra Leone epidemiologySierra Leone epidemiologySierra Leone epidemiologySierra Leone epidemiologySierra Leone epidemiologySwineSwineSwineSwineSwineSwineGuinea epidemiologyGuinea epidemiologyGuinea epidemiologyGuinea epidemiologyGuinea epidemiologyGuinea epidemiologyHemorrhagic Fever, Ebola epidemiologyHemorrhagic Fever, Ebola epidemiologyHemorrhagic Fever, Ebola epidemiologyHemorrhagic Fever, Ebola epidemiologyHemorrhagic Fever, Ebola epidemiologyHemorrhagic Fever, Ebola epidemiologyHemorrhagic Fever, Ebola veterinaryHemorrhagic Fever, Ebola veterinaryHemorrhagic Fever, Ebola veterinaryHemorrhagic Fever, Ebola veterinaryHemorrhagic Fever, Ebola veterinaryHemorrhagic Fever, Ebola veterinaryEbolavirusEbolavirusEbolavirusEbolavirusEbolavirusEbolavirusSus scrofaSus scrofaSus scrofaSus scrofaSus scrofaSus scrofaHealth Sciences Medicine Infectious Diseases Viral Infections and Outbreaks ResearchHealth Sciences Medicine Infectious Diseases Viral Infections and VectorsHealth Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiologyAlthough pigs are naturally susceptible to Reston virus and experimentally to Ebola virus (EBOV), their role in Orthoebolavirus ecology remains unknown. We tested 888 serum samples collected from pigs in Guinea during 2017-2019 (between the 2013-16 epidemic and its resurgence in 2021) by indirect ELISA against the EBOV nucleoprotein. We identified 2 hotspots of possible pig exposure by IgG titer levels: the northern coast had 48.7% of positive serum samples (37/76), and Forest Guinea, bordering Sierra Leone and Liberia, where the virus emerged and reemerged, had 50% of positive serum samples (98/196). The multitarget Luminex approach confirms ELISA results against Ebola nucleoprotein and highlights cross-reactivities to glycoprotein of EBOV, Reston virus, and Bundibugyo virus. Those results are consistent with previous observations of the circulation of Orthoebolavirus species in pig farming regions in Sierra Leone and Ghana, suggesting potential risk for Ebola virus disease in humans, especially in Forest Guinea.Articlehttps://pubmed.ncbi.nlm.nih.gov/38526081https://wwwnc.cdc.gov/eid/article/30/4/pdfs/23-1034.pdfhttps://doi.org/10.3201/eid3004.23103410.3201/eid3004.231034https://hdl.handle.net/20.500.15037/1733W4393080767enEmerging infectious diseases1080-60401080-60592024-03-222026-06-13T14:20:05Z2026-06-13T14:20:05Z |
| spellingShingle | Sierra leone Ebola virus Virology Nucleoprotein Virus Ebolavirus Biology Population Titer Marburg virus Guinea pig Medicine Socioeconomics Environmental health Endocrinology Sociology Sierra leone Ebola virus Virology Nucleoprotein Virus Ebolavirus Biology Population Titer Marburg virus Guinea pig Medicine Socioeconomics Environmental health Animals Animals Animals Animals Animals Animals Humans Humans Humans Humans Humans Humans Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Swine Swine Swine Swine Swine Swine Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Ebolavirus Ebolavirus Ebolavirus Ebolavirus Ebolavirus Ebolavirus Sus scrofa Sus scrofa Sus scrofa Sus scrofa Sus scrofa Sus scrofa Health Sciences Medicine Infectious Diseases Viral Infections and Outbreaks Research Health Sciences Medicine Infectious Diseases Viral Infections and Vectors Health Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiology Solène Grayo Alimou Camara Bakary Doukouré Isabelle Ellis Cécile Troupin Kerstin Fischer Jessica Vanhomwegen Michaël White Martin H. Groschup Sandra Diederich Noël Tordo Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019 |
| title | Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019 |
| title_full | Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019 |
| title_fullStr | Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019 |
| title_full_unstemmed | Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019 |
| title_short | Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019 |
| title_sort | geographic disparities in domestic pig population exposure to ebola viruses guinea 2017 2019 |
| topic | Sierra leone Ebola virus Virology Nucleoprotein Virus Ebolavirus Biology Population Titer Marburg virus Guinea pig Medicine Socioeconomics Environmental health Endocrinology Sociology Sierra leone Ebola virus Virology Nucleoprotein Virus Ebolavirus Biology Population Titer Marburg virus Guinea pig Medicine Socioeconomics Environmental health Animals Animals Animals Animals Animals Animals Humans Humans Humans Humans Humans Humans Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Swine Swine Swine Swine Swine Swine Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Ebolavirus Ebolavirus Ebolavirus Ebolavirus Ebolavirus Ebolavirus Sus scrofa Sus scrofa Sus scrofa Sus scrofa Sus scrofa Sus scrofa Health Sciences Medicine Infectious Diseases Viral Infections and Outbreaks Research Health Sciences Medicine Infectious Diseases Viral Infections and Vectors Health Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiology |
| topic_facet | Sierra leone Ebola virus Virology Nucleoprotein Virus Ebolavirus Biology Population Titer Marburg virus Guinea pig Medicine Socioeconomics Environmental health Endocrinology Sociology Sierra leone Ebola virus Virology Nucleoprotein Virus Ebolavirus Biology Population Titer Marburg virus Guinea pig Medicine Socioeconomics Environmental health Animals Animals Animals Animals Animals Animals Humans Humans Humans Humans Humans Humans Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Nucleoproteins genetics Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Sierra Leone epidemiology Swine Swine Swine Swine Swine Swine Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Guinea epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola epidemiology Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Hemorrhagic Fever, Ebola veterinary Ebolavirus Ebolavirus Ebolavirus Ebolavirus Ebolavirus Ebolavirus Sus scrofa Sus scrofa Sus scrofa Sus scrofa Sus scrofa Sus scrofa Health Sciences Medicine Infectious Diseases Viral Infections and Outbreaks Research Health Sciences Medicine Infectious Diseases Viral Infections and Vectors Health Sciences Medicine Infectious Diseases Viral gastroenteritis research and epidemiology |
| url | https://pubmed.ncbi.nlm.nih.gov/38526081 https://wwwnc.cdc.gov/eid/article/30/4/pdfs/23-1034.pdf https://doi.org/10.3201/eid3004.231034 https://hdl.handle.net/20.500.15037/1733 |
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