Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients
To determine whether hepatic hypoxia is associated with hepatocellular necrosis in alcoholics, oxygen tension in the hepatic vein and hepatic blood flow were determined in thirteen patients without overt clinical liver disease. Ethanol metabolic rate was also assayed as an index of liver metabolism....
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1980
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| _version_ | 1881508869044174848 |
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| author | H Iturriaga G Ugarte Yedi Israel |
| author_browse | G Ugarte H Iturriaga Yedi Israel |
| author_facet | H Iturriaga G Ugarte Yedi Israel |
| author_sort | H Iturriaga |
| collection | Producción científica |
| description | To determine whether hepatic hypoxia is associated with hepatocellular necrosis in alcoholics, oxygen tension in the hepatic vein and hepatic blood flow were determined in thirteen patients without overt clinical liver disease. Ethanol metabolic rate was also assayed as an index of liver metabolism. Hepatic blood flow and ethanol metabolic rate were also determined in six normal volunteers. According to liver histology patients were separated into two groups, with and without hepatocellular necrosis. Alcoholics with necrosis showed a higher (P less than 0.002) ethanol metabolic rate (4.05 +/- 0.23 mmol/kg/h) than those without necrosis (2.46 +/- 0.34). Hepatic blood flow in the total group of alcoholics was not significantly different from controls; in the group with necrosis it was lower (651.7 +/- 44.6 ml/min/m2) than in the group without necrosis (878.3 +/- 81.6; P less than 0.025). Hepatic vein pO2 was lower (P less than 0.01) in patients with hepatocellular necrosis (31.7 +/- 0.68 mmHg) than in patients without necrosis (35.7 +/- 0.99). In the whole group, a significant negative correlation (r = 0.76, P less than 0.003) was observed between hepatic vein pO2 and ethanol metabolic rate. Acute administration of ethanol (21.7 mmol/kg) did not alter hepatic blood flow in six normal individuals nor in five alcoholic patients, although an increase in hepatic vein pO2 was observed in the latter. The changes observed in hepatic vein pO2 functional hepatic blood flow, and ethanol metabolic rate which correlate with hepatocellular necrosis, may be of pathogenic importance in alcoholic liver disease. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1678 |
| institution | UPeU |
| language | English |
| publishDate | 1980 |
| publishDateRange | 1980 |
| publishDateSort | 1980 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/16782026-10-30T16:16:27ZHepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patientsH IturriagaG UgarteYedi IsraelOxygenationBlood flowPortal veinMedicineAlcoholic liver diseaseEthanolInternal medicineCardiologyChemistryCirrhosisBiochemistryOxygenationBlood flowPortal veinMedicineAlcoholic liver diseaseEthanolInternal medicineCardiologyChemistryCirrhosisBiochemistryAdultAdultAdultEthanol metabolismEthanol metabolismEthanol metabolismAlcoholism metabolismAlcoholism metabolismAlcoholism metabolismBlood Flow VelocityBlood Flow VelocityBlood Flow VelocityDose-Response Relationship, DrugDose-Response Relationship, DrugDose-Response Relationship, DrugHemodynamicsHemodynamicsHemodynamicsHepatic Veins physiologyHepatic Veins physiologyHepatic Veins physiologyHumansHumansHumansLiver blood supplyLiver blood supplyLiver blood supplyLiver metabolismLiver metabolismLiver metabolismLiver Diseases, Alcoholic metabolismLiver Diseases, Alcoholic metabolismLiver Diseases, Alcoholic metabolismMaleMaleMaleMetabolic Clearance RateMetabolic Clearance RateMetabolic Clearance RateMiddle AgedMiddle AgedMiddle AgedOxygen bloodOxygen bloodOxygen bloodPartial PressurePartial PressurePartial PressureHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsLife Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension PharmacologyHealth Sciences Medicine Hepatology Liver Disease and TransplantationTo determine whether hepatic hypoxia is associated with hepatocellular necrosis in alcoholics, oxygen tension in the hepatic vein and hepatic blood flow were determined in thirteen patients without overt clinical liver disease. Ethanol metabolic rate was also assayed as an index of liver metabolism. Hepatic blood flow and ethanol metabolic rate were also determined in six normal volunteers. According to liver histology patients were separated into two groups, with and without hepatocellular necrosis. Alcoholics with necrosis showed a higher (P less than 0.002) ethanol metabolic rate (4.05 +/- 0.23 mmol/kg/h) than those without necrosis (2.46 +/- 0.34). Hepatic blood flow in the total group of alcoholics was not significantly different from controls; in the group with necrosis it was lower (651.7 +/- 44.6 ml/min/m2) than in the group without necrosis (878.3 +/- 81.6; P less than 0.025). Hepatic vein pO2 was lower (P less than 0.01) in patients with hepatocellular necrosis (31.7 +/- 0.68 mmHg) than in patients without necrosis (35.7 +/- 0.99). In the whole group, a significant negative correlation (r = 0.76, P less than 0.003) was observed between hepatic vein pO2 and ethanol metabolic rate. Acute administration of ethanol (21.7 mmol/kg) did not alter hepatic blood flow in six normal individuals nor in five alcoholic patients, although an increase in hepatic vein pO2 was observed in the latter. The changes observed in hepatic vein pO2 functional hepatic blood flow, and ethanol metabolic rate which correlate with hepatocellular necrosis, may be of pathogenic importance in alcoholic liver disease.Articlehttps://pubmed.ncbi.nlm.nih.gov/678341710.1111/j.1365-2362.1980.tb00022.xhttps://hdl.handle.net/20.500.15037/1678W2100670289enEuropean Journal of Clinical Investigation0014-29721365-23621980-06-012026-06-13T14:18:34Z2026-06-13T14:18:34Z |
| spellingShingle | Oxygenation Blood flow Portal vein Medicine Alcoholic liver disease Ethanol Internal medicine Cardiology Chemistry Cirrhosis Biochemistry Oxygenation Blood flow Portal vein Medicine Alcoholic liver disease Ethanol Internal medicine Cardiology Chemistry Cirrhosis Biochemistry Adult Adult Adult Ethanol metabolism Ethanol metabolism Ethanol metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Blood Flow Velocity Blood Flow Velocity Blood Flow Velocity Dose-Response Relationship, Drug Dose-Response Relationship, Drug Dose-Response Relationship, Drug Hemodynamics Hemodynamics Hemodynamics Hepatic Veins physiology Hepatic Veins physiology Hepatic Veins physiology Humans Humans Humans Liver blood supply Liver blood supply Liver blood supply Liver metabolism Liver metabolism Liver metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Male Male Male Metabolic Clearance Rate Metabolic Clearance Rate Metabolic Clearance Rate Middle Aged Middle Aged Middle Aged Oxygen blood Oxygen blood Oxygen blood Partial Pressure Partial Pressure Partial Pressure Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Hepatology Liver Disease and Transplantation H Iturriaga G Ugarte Yedi Israel Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients |
| title | Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients |
| title_full | Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients |
| title_fullStr | Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients |
| title_full_unstemmed | Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients |
| title_short | Hepatic vein oxygenation, liver blood flow, and the rate of ethanol metabolism in recently abstinent alcoholic patients |
| title_sort | hepatic vein oxygenation liver blood flow and the rate of ethanol metabolism in recently abstinent alcoholic patients |
| topic | Oxygenation Blood flow Portal vein Medicine Alcoholic liver disease Ethanol Internal medicine Cardiology Chemistry Cirrhosis Biochemistry Oxygenation Blood flow Portal vein Medicine Alcoholic liver disease Ethanol Internal medicine Cardiology Chemistry Cirrhosis Biochemistry Adult Adult Adult Ethanol metabolism Ethanol metabolism Ethanol metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Blood Flow Velocity Blood Flow Velocity Blood Flow Velocity Dose-Response Relationship, Drug Dose-Response Relationship, Drug Dose-Response Relationship, Drug Hemodynamics Hemodynamics Hemodynamics Hepatic Veins physiology Hepatic Veins physiology Hepatic Veins physiology Humans Humans Humans Liver blood supply Liver blood supply Liver blood supply Liver metabolism Liver metabolism Liver metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Male Male Male Metabolic Clearance Rate Metabolic Clearance Rate Metabolic Clearance Rate Middle Aged Middle Aged Middle Aged Oxygen blood Oxygen blood Oxygen blood Partial Pressure Partial Pressure Partial Pressure Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Hepatology Liver Disease and Transplantation |
| topic_facet | Oxygenation Blood flow Portal vein Medicine Alcoholic liver disease Ethanol Internal medicine Cardiology Chemistry Cirrhosis Biochemistry Oxygenation Blood flow Portal vein Medicine Alcoholic liver disease Ethanol Internal medicine Cardiology Chemistry Cirrhosis Biochemistry Adult Adult Adult Ethanol metabolism Ethanol metabolism Ethanol metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Blood Flow Velocity Blood Flow Velocity Blood Flow Velocity Dose-Response Relationship, Drug Dose-Response Relationship, Drug Dose-Response Relationship, Drug Hemodynamics Hemodynamics Hemodynamics Hepatic Veins physiology Hepatic Veins physiology Hepatic Veins physiology Humans Humans Humans Liver blood supply Liver blood supply Liver blood supply Liver metabolism Liver metabolism Liver metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Male Male Male Metabolic Clearance Rate Metabolic Clearance Rate Metabolic Clearance Rate Middle Aged Middle Aged Middle Aged Oxygen blood Oxygen blood Oxygen blood Partial Pressure Partial Pressure Partial Pressure Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Hepatology Liver Disease and Transplantation |
| url | https://pubmed.ncbi.nlm.nih.gov/6783417 https://hdl.handle.net/20.500.15037/1678 |
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