Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis
1. The relationship between the content of hepatic reduced glutathione (GSH) and the length of abstinence was investigated in 45 chronic alcoholic patients. 2. Hepatic GSH levels were significantly correlated (r = 0.58; P<0.001) with the length of alcohol withdrawal in the whole group. According...
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1984
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| _version_ | 1881508963742121984 |
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| author | Luis A. Videla H Iturriaga María Eugenia Pino Daniel Bunout Alfonso Valenzuela G Ugarte |
| author_browse | Alfonso Valenzuela Daniel Bunout G Ugarte H Iturriaga Luis A. Videla María Eugenia Pino |
| author_facet | Luis A. Videla H Iturriaga María Eugenia Pino Daniel Bunout Alfonso Valenzuela G Ugarte |
| author_sort | Luis A. Videla |
| collection | Producción científica |
| description | 1. The relationship between the content of hepatic reduced glutathione (GSH) and the length of abstinence was investigated in 45 chronic alcoholic patients. 2. Hepatic GSH levels were significantly correlated (r = 0.58; P<0.001) with the length of alcohol withdrawal in the whole group. According to liver histology patients were divided into two groups, with and without hepatic necrosis. Subjects without necrosis showed a significant positive correlation (r = 0.71; P<0.001) between GSH values and the length of abstinence; no correlation (r = −0.22; P<0.40) was observed in the group with necrosis. 3. According to the period of abstinence patients were separated into two groups, with a short (≪ 5 days) and a prolonged (> 5 days) alcohol withdrawal. Patients with and without necrosis exhibited comparable mean levels of liver GSH (2.04 ± sem 0.21 and 1.74 ± 0.23 μmol/g respectively; P<0.30) when studied after short periods of abstinence. Alcoholics without liver necrosis showed significantly higher hepatic GSH levels than those with necrosis (3.23 ± 0.30 and 1.60 ± 0.33 respectively; P < 0.01) after prolonged periods of alcohol withdrawal. Similar results were obtained when liver GSH levels were expressed as a function of the mean surface area of hepatocytes, which was not significantly different between patients with and without hepatic necrosis. 4. Parameters assessing the nutritional status of patients with and without necrosis were not significantly different. Steatosis, histologically scored and irrespective of the period of abstinence, was higher in patients with liver necrosis and it did not correlate with hepatic GSH (r = −0.17; not significant). Fibrosis was observed in 20 cases and it did not modify the positive correlation between liver GSH content and the period of abstinence (with fibrosis: r = 0.57; P < 0.01; without fibrosis: r = 0.58;P < 0.01). 5. The changes observed in liver GSH content might be of pathogenic importance in alcoholic liver disease through alterations in lipoperoxidative processes in the hepatocyte. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1673 |
| institution | UPeU |
| language | English |
| publishDate | 1984 |
| publishDateRange | 1984 |
| publishDateSort | 1984 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/16732026-10-30T16:16:26ZContent of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver NecrosisLuis A. VidelaH IturriagaMaría Eugenia PinoDaniel BunoutAlfonso ValenzuelaG UgarteAbstinenceNecrosisGlutathioneInternal medicineSteatosisEndocrinologyAlcoholic liver diseaseMedicineGastroenterologyCirrhosisChemistryBiochemistryPsychiatryEnzymeAbstinenceNecrosisGlutathioneInternal medicineSteatosisEndocrinologyAlcoholic liver diseaseMedicineGastroenterologyCirrhosisChemistryBiochemistryPsychiatryAdultAdultAdultAlcoholism metabolismAlcoholism metabolismAlcoholism metabolismAlcoholism pathologyAlcoholism pathologyAlcoholism pathologyAlcoholism therapyAlcoholism therapyAlcoholism therapyGlutathione metabolismGlutathione metabolismGlutathione metabolismHumansHumansHumansLiver metabolismLiver metabolismLiver metabolismLiver pathologyLiver pathologyLiver pathologyLiver Diseases, Alcoholic metabolismLiver Diseases, Alcoholic metabolismLiver Diseases, Alcoholic metabolismLiver Diseases, Alcoholic pathologyLiver Diseases, Alcoholic pathologyLiver Diseases, Alcoholic pathologyLiver Diseases, Alcoholic therapyLiver Diseases, Alcoholic therapyLiver Diseases, Alcoholic therapyMaleMaleMaleNecrosisNecrosisNecrosisNutritional Physiological PhenomenaNutritional Physiological PhenomenaNutritional Physiological PhenomenaOxidation-ReductionOxidation-ReductionOxidation-ReductionTime FactorsTime FactorsTime FactorsHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsLife Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in BiologyHealth Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment1. The relationship between the content of hepatic reduced glutathione (GSH) and the length of abstinence was investigated in 45 chronic alcoholic patients. 2. Hepatic GSH levels were significantly correlated (r = 0.58; P<0.001) with the length of alcohol withdrawal in the whole group. According to liver histology patients were divided into two groups, with and without hepatic necrosis. Subjects without necrosis showed a significant positive correlation (r = 0.71; P<0.001) between GSH values and the length of abstinence; no correlation (r = −0.22; P<0.40) was observed in the group with necrosis. 3. According to the period of abstinence patients were separated into two groups, with a short (≪ 5 days) and a prolonged (> 5 days) alcohol withdrawal. Patients with and without necrosis exhibited comparable mean levels of liver GSH (2.04 ± sem 0.21 and 1.74 ± 0.23 μmol/g respectively; P<0.30) when studied after short periods of abstinence. Alcoholics without liver necrosis showed significantly higher hepatic GSH levels than those with necrosis (3.23 ± 0.30 and 1.60 ± 0.33 respectively; P < 0.01) after prolonged periods of alcohol withdrawal. Similar results were obtained when liver GSH levels were expressed as a function of the mean surface area of hepatocytes, which was not significantly different between patients with and without hepatic necrosis. 4. Parameters assessing the nutritional status of patients with and without necrosis were not significantly different. Steatosis, histologically scored and irrespective of the period of abstinence, was higher in patients with liver necrosis and it did not correlate with hepatic GSH (r = −0.17; not significant). Fibrosis was observed in 20 cases and it did not modify the positive correlation between liver GSH content and the period of abstinence (with fibrosis: r = 0.57; P < 0.01; without fibrosis: r = 0.58;P < 0.01). 5. The changes observed in liver GSH content might be of pathogenic importance in alcoholic liver disease through alterations in lipoperoxidative processes in the hepatocyte.Articlehttps://pubmed.ncbi.nlm.nih.gov/6692660http://repositorio.uchile.cl/handle/2250/16053410.1042/cs0660283https://hdl.handle.net/20.500.15037/1673W2423852222enClinical Science0143-52211470-87361984-03-012026-06-13T14:18:26Z2026-06-13T14:18:26Z |
| spellingShingle | Abstinence Necrosis Glutathione Internal medicine Steatosis Endocrinology Alcoholic liver disease Medicine Gastroenterology Cirrhosis Chemistry Biochemistry Psychiatry Enzyme Abstinence Necrosis Glutathione Internal medicine Steatosis Endocrinology Alcoholic liver disease Medicine Gastroenterology Cirrhosis Chemistry Biochemistry Psychiatry Adult Adult Adult Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism pathology Alcoholism pathology Alcoholism pathology Alcoholism therapy Alcoholism therapy Alcoholism therapy Glutathione metabolism Glutathione metabolism Glutathione metabolism Humans Humans Humans Liver metabolism Liver metabolism Liver metabolism Liver pathology Liver pathology Liver pathology Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic therapy Liver Diseases, Alcoholic therapy Liver Diseases, Alcoholic therapy Male Male Male Necrosis Necrosis Necrosis Nutritional Physiological Phenomena Nutritional Physiological Phenomena Nutritional Physiological Phenomena Oxidation-Reduction Oxidation-Reduction Oxidation-Reduction Time Factors Time Factors Time Factors Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in Biology Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Luis A. Videla H Iturriaga María Eugenia Pino Daniel Bunout Alfonso Valenzuela G Ugarte Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis |
| title | Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis |
| title_full | Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis |
| title_fullStr | Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis |
| title_full_unstemmed | Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis |
| title_short | Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis |
| title_sort | content of hepatic reduced glutathione in chronic alcoholic patients influence of the length of abstinence and liver necrosis |
| topic | Abstinence Necrosis Glutathione Internal medicine Steatosis Endocrinology Alcoholic liver disease Medicine Gastroenterology Cirrhosis Chemistry Biochemistry Psychiatry Enzyme Abstinence Necrosis Glutathione Internal medicine Steatosis Endocrinology Alcoholic liver disease Medicine Gastroenterology Cirrhosis Chemistry Biochemistry Psychiatry Adult Adult Adult Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism pathology Alcoholism pathology Alcoholism pathology Alcoholism therapy Alcoholism therapy Alcoholism therapy Glutathione metabolism Glutathione metabolism Glutathione metabolism Humans Humans Humans Liver metabolism Liver metabolism Liver metabolism Liver pathology Liver pathology Liver pathology Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic therapy Liver Diseases, Alcoholic therapy Liver Diseases, Alcoholic therapy Male Male Male Necrosis Necrosis Necrosis Nutritional Physiological Phenomena Nutritional Physiological Phenomena Nutritional Physiological Phenomena Oxidation-Reduction Oxidation-Reduction Oxidation-Reduction Time Factors Time Factors Time Factors Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in Biology Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment |
| topic_facet | Abstinence Necrosis Glutathione Internal medicine Steatosis Endocrinology Alcoholic liver disease Medicine Gastroenterology Cirrhosis Chemistry Biochemistry Psychiatry Enzyme Abstinence Necrosis Glutathione Internal medicine Steatosis Endocrinology Alcoholic liver disease Medicine Gastroenterology Cirrhosis Chemistry Biochemistry Psychiatry Adult Adult Adult Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Alcoholism pathology Alcoholism pathology Alcoholism pathology Alcoholism therapy Alcoholism therapy Alcoholism therapy Glutathione metabolism Glutathione metabolism Glutathione metabolism Humans Humans Humans Liver metabolism Liver metabolism Liver metabolism Liver pathology Liver pathology Liver pathology Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic metabolism Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic pathology Liver Diseases, Alcoholic therapy Liver Diseases, Alcoholic therapy Liver Diseases, Alcoholic therapy Male Male Male Necrosis Necrosis Necrosis Nutritional Physiological Phenomena Nutritional Physiological Phenomena Nutritional Physiological Phenomena Oxidation-Reduction Oxidation-Reduction Oxidation-Reduction Time Factors Time Factors Time Factors Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in Biology Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment |
| url | https://pubmed.ncbi.nlm.nih.gov/6692660 http://repositorio.uchile.cl/handle/2250/160534 https://hdl.handle.net/20.500.15037/1673 |
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