Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage
Glucose intolerance is frequently found in alcoholic patients and an impaired insulin response has been documented in them. To look for alternative mechanisms that could explain this intolerance, a glucose turnover using tritiated glucose and an euglycemic glucose clamp were performed to measure the...
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| Formato: | Artículo |
| Lenguaje: | inglés |
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1989
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| _version_ | 1881508868470603776 |
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| author | Daniel Bunout Marcus Petermann M. Bravo Mary M. Kelly S Hirsch G Ugarte H Iturriaga |
| author_browse | Daniel Bunout G Ugarte H Iturriaga M. Bravo Marcus Petermann Mary M. Kelly S Hirsch |
| author_facet | Daniel Bunout Marcus Petermann M. Bravo Mary M. Kelly S Hirsch G Ugarte H Iturriaga |
| author_sort | Daniel Bunout |
| collection | Producción científica |
| description | Glucose intolerance is frequently found in alcoholic patients and an impaired insulin response has been documented in them. To look for alternative mechanisms that could explain this intolerance, a glucose turnover using tritiated glucose and an euglycemic glucose clamp were performed to measure the glucose production rate and peripheral insulin sensitivity, respectively. Two groups of recently abstinent chronic male alcoholic patients without evidence of liver damage were studied. The glucose turnover technique showed a higher basal glucose production rate in alcoholics, compared with normal volunteers (2.83 +/- 0.29 vs. 1.84 +/- 0.22 mg/kg/min); an intravenous ethanol load significantly increased this rate. The euglycemic glucose clamp did not show peripheral insulin resistance in alcoholics, compared with controls. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1667 |
| institution | UPeU |
| language | English |
| publishDate | 1989 |
| publishDateRange | 1989 |
| publishDateSort | 1989 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/16672026-10-30T16:16:25ZGlucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver DamageDaniel BunoutMarcus PetermannM. BravoMary M. KellyS HirschG UgarteH IturriagaInternal medicineEndocrinologyGlucose clamp techniqueBasal (medicine)InsulinInsulin resistanceClampGlucose uptakePeripheralCarbohydrate metabolismImpaired glucose toleranceMedicineTurnoverDiabetes mellitusInsulin sensitivityMechanical engineeringEconomicsEngineeringClampingManagementInternal medicineEndocrinologyGlucose clamp techniqueBasal (medicine)InsulinInsulin resistanceClampGlucose uptakePeripheralCarbohydrate metabolismImpaired glucose toleranceMedicineTurnoverDiabetes mellitusInsulin sensitivityAdultAdultAdultAlcoholism metabolismAlcoholism metabolismAlcoholism metabolismGlucose metabolismGlucose metabolismGlucose metabolismHumansHumansHumansInsulin ResistanceInsulin ResistanceInsulin ResistanceLiver metabolismLiver metabolismLiver metabolismMaleMaleMaleMiddle AgedMiddle AgedMiddle AgedGlucose Clamp TechniqueGlucose Clamp TechniqueGlucose Clamp TechniqueHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsHealth Sciences Medicine Epidemiology Liver Disease Diagnosis and TreatmentHealth Sciences Medicine Neurology Alcoholism and Thiamine DeficiencyGlucose intolerance is frequently found in alcoholic patients and an impaired insulin response has been documented in them. To look for alternative mechanisms that could explain this intolerance, a glucose turnover using tritiated glucose and an euglycemic glucose clamp were performed to measure the glucose production rate and peripheral insulin sensitivity, respectively. Two groups of recently abstinent chronic male alcoholic patients without evidence of liver damage were studied. The glucose turnover technique showed a higher basal glucose production rate in alcoholics, compared with normal volunteers (2.83 +/- 0.29 vs. 1.84 +/- 0.22 mg/kg/min); an intravenous ethanol load significantly increased this rate. The euglycemic glucose clamp did not show peripheral insulin resistance in alcoholics, compared with controls.Articlehttps://pubmed.ncbi.nlm.nih.gov/2662885http://repositorio.uchile.cl/handle/2250/16072810.1159/000177518https://hdl.handle.net/20.500.15037/1667W1970738711enAnnals of Nutrition and Metabolism0250-68071421-96971989-01-012026-06-13T14:18:15Z2026-06-13T14:18:15Z |
| spellingShingle | Internal medicine Endocrinology Glucose clamp technique Basal (medicine) Insulin Insulin resistance Clamp Glucose uptake Peripheral Carbohydrate metabolism Impaired glucose tolerance Medicine Turnover Diabetes mellitus Insulin sensitivity Mechanical engineering Economics Engineering Clamping Management Internal medicine Endocrinology Glucose clamp technique Basal (medicine) Insulin Insulin resistance Clamp Glucose uptake Peripheral Carbohydrate metabolism Impaired glucose tolerance Medicine Turnover Diabetes mellitus Insulin sensitivity Adult Adult Adult Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Glucose metabolism Glucose metabolism Glucose metabolism Humans Humans Humans Insulin Resistance Insulin Resistance Insulin Resistance Liver metabolism Liver metabolism Liver metabolism Male Male Male Middle Aged Middle Aged Middle Aged Glucose Clamp Technique Glucose Clamp Technique Glucose Clamp Technique Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Neurology Alcoholism and Thiamine Deficiency Daniel Bunout Marcus Petermann M. Bravo Mary M. Kelly S Hirsch G Ugarte H Iturriaga Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage |
| title | Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage |
| title_full | Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage |
| title_fullStr | Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage |
| title_full_unstemmed | Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage |
| title_short | Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage |
| title_sort | glucose turnover rate and peripheral insulin sensitivity in alcoholic patients without liver damage |
| topic | Internal medicine Endocrinology Glucose clamp technique Basal (medicine) Insulin Insulin resistance Clamp Glucose uptake Peripheral Carbohydrate metabolism Impaired glucose tolerance Medicine Turnover Diabetes mellitus Insulin sensitivity Mechanical engineering Economics Engineering Clamping Management Internal medicine Endocrinology Glucose clamp technique Basal (medicine) Insulin Insulin resistance Clamp Glucose uptake Peripheral Carbohydrate metabolism Impaired glucose tolerance Medicine Turnover Diabetes mellitus Insulin sensitivity Adult Adult Adult Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Glucose metabolism Glucose metabolism Glucose metabolism Humans Humans Humans Insulin Resistance Insulin Resistance Insulin Resistance Liver metabolism Liver metabolism Liver metabolism Male Male Male Middle Aged Middle Aged Middle Aged Glucose Clamp Technique Glucose Clamp Technique Glucose Clamp Technique Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Neurology Alcoholism and Thiamine Deficiency |
| topic_facet | Internal medicine Endocrinology Glucose clamp technique Basal (medicine) Insulin Insulin resistance Clamp Glucose uptake Peripheral Carbohydrate metabolism Impaired glucose tolerance Medicine Turnover Diabetes mellitus Insulin sensitivity Mechanical engineering Economics Engineering Clamping Management Internal medicine Endocrinology Glucose clamp technique Basal (medicine) Insulin Insulin resistance Clamp Glucose uptake Peripheral Carbohydrate metabolism Impaired glucose tolerance Medicine Turnover Diabetes mellitus Insulin sensitivity Adult Adult Adult Alcoholism metabolism Alcoholism metabolism Alcoholism metabolism Glucose metabolism Glucose metabolism Glucose metabolism Humans Humans Humans Insulin Resistance Insulin Resistance Insulin Resistance Liver metabolism Liver metabolism Liver metabolism Male Male Male Middle Aged Middle Aged Middle Aged Glucose Clamp Technique Glucose Clamp Technique Glucose Clamp Technique Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Neurology Alcoholism and Thiamine Deficiency |
| url | https://pubmed.ncbi.nlm.nih.gov/2662885 http://repositorio.uchile.cl/handle/2250/160728 https://hdl.handle.net/20.500.15037/1667 |
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