Controlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic Cirrhosis
A controlled trial on nutrition supplementation in ambulatory patients with decompensated alcoholic liver disease was carried out during 1 year. Fifty-one patients were studied; 26 were assigned to an experimental group receiving a daily supplement of 1000 kcal and 34 g of proteins given as a casein...
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1993
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| author | Sandra Hirsch Daniel Bunout Pı́a de la Maza H Iturriaga Margarita Petermann Gloria Icazar V Gattás G Ugarte |
| author_browse | Daniel Bunout G Ugarte Gloria Icazar H Iturriaga Margarita Petermann Pı́a de la Maza Sandra Hirsch V Gattás |
| author_facet | Sandra Hirsch Daniel Bunout Pı́a de la Maza H Iturriaga Margarita Petermann Gloria Icazar V Gattás G Ugarte |
| author_sort | Sandra Hirsch |
| collection | Producción científica |
| description | A controlled trial on nutrition supplementation in ambulatory patients with decompensated alcoholic liver disease was carried out during 1 year. Fifty-one patients were studied; 26 were assigned to an experimental group receiving a daily supplement of 1000 kcal and 34 g of proteins given as a casein-based enteral nutrition product and 25 to a control group receiving one placebo capsule. Patients were examined in a special clinic once a month or more if required. Sixty-eight percent of patients admitted to alcohol ingestion or had alcohol in urine samples on at least one occasion. Dietary recalls showed a significantly higher protein and caloric intake in case patients subjects (p < .0001). Nine patients died during the study, three case patients and six control patients (p = NS). The frequency of hospitalizations was significantly less in the experimental group. This difference was attributed to a reduction in severe infections. Mid-arm circumference, serum albumin concentration, and hand grip strength improved earlier in case patients, although both groups had a significant improvement in these parameters. Bilirubin and aspartate aminotransferase decreased and prothrombin time increased significantly in both groups during the study period, without differences between groups. It is concluded that nutrition support decreases nutrition-associated complications in patients with alcoholic liver disease. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1664 |
| institution | UPeU |
| language | English |
| publishDate | 1993 |
| publishDateRange | 1993 |
| publishDateSort | 1993 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/16642026-10-30T16:16:25ZControlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic CirrhosisSandra HirschDaniel BunoutPı́a de la MazaH IturriagaMargarita PetermannGloria IcazarV GattásG UgarteMedicineParenteral nutritionInternal medicineGastroenterologyAlcoholic liver diseasePlaceboCirrhosisLiver diseaseRandomized controlled trialAlternative medicinePathologyMedicineParenteral nutritionInternal medicineGastroenterologyAlcoholic liver diseasePlaceboCirrhosisLiver diseaseRandomized controlled trialAdultAdultAdultAmbulatory CareAmbulatory CareAmbulatory CareEnteral NutritionEnteral NutritionEnteral NutritionFemaleFemaleFemaleHumansHumansHumansLiver Cirrhosis, Alcoholic therapyLiver Cirrhosis, Alcoholic therapyLiver Cirrhosis, Alcoholic therapyMaleMaleMaleMiddle AgedMiddle AgedMiddle AgedTime FactorsTime FactorsTime FactorsHealth Sciences Medicine Epidemiology Liver Disease Diagnosis and TreatmentHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsHealth Sciences Medicine Hepatology Liver Disease and TransplantationA controlled trial on nutrition supplementation in ambulatory patients with decompensated alcoholic liver disease was carried out during 1 year. Fifty-one patients were studied; 26 were assigned to an experimental group receiving a daily supplement of 1000 kcal and 34 g of proteins given as a casein-based enteral nutrition product and 25 to a control group receiving one placebo capsule. Patients were examined in a special clinic once a month or more if required. Sixty-eight percent of patients admitted to alcohol ingestion or had alcohol in urine samples on at least one occasion. Dietary recalls showed a significantly higher protein and caloric intake in case patients subjects (p < .0001). Nine patients died during the study, three case patients and six control patients (p = NS). The frequency of hospitalizations was significantly less in the experimental group. This difference was attributed to a reduction in severe infections. Mid-arm circumference, serum albumin concentration, and hand grip strength improved earlier in case patients, although both groups had a significant improvement in these parameters. Bilirubin and aspartate aminotransferase decreased and prothrombin time increased significantly in both groups during the study period, without differences between groups. It is concluded that nutrition support decreases nutrition-associated complications in patients with alcoholic liver disease.Articlehttps://pubmed.ncbi.nlm.nih.gov/845531210.1177/0148607193017002119https://hdl.handle.net/20.500.15037/1664W1981085899enJournal of Parenteral and Enteral Nutrition0148-60711941-24441993-03-012026-06-13T14:18:10Z2026-06-13T14:18:10Z |
| spellingShingle | Medicine Parenteral nutrition Internal medicine Gastroenterology Alcoholic liver disease Placebo Cirrhosis Liver disease Randomized controlled trial Alternative medicine Pathology Medicine Parenteral nutrition Internal medicine Gastroenterology Alcoholic liver disease Placebo Cirrhosis Liver disease Randomized controlled trial Adult Adult Adult Ambulatory Care Ambulatory Care Ambulatory Care Enteral Nutrition Enteral Nutrition Enteral Nutrition Female Female Female Humans Humans Humans Liver Cirrhosis, Alcoholic therapy Liver Cirrhosis, Alcoholic therapy Liver Cirrhosis, Alcoholic therapy Male Male Male Middle Aged Middle Aged Middle Aged Time Factors Time Factors Time Factors Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Hepatology Liver Disease and Transplantation Sandra Hirsch Daniel Bunout Pı́a de la Maza H Iturriaga Margarita Petermann Gloria Icazar V Gattás G Ugarte Controlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic Cirrhosis |
| title | Controlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic Cirrhosis |
| title_full | Controlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic Cirrhosis |
| title_fullStr | Controlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic Cirrhosis |
| title_full_unstemmed | Controlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic Cirrhosis |
| title_short | Controlled Trial on Nutrition Supplementation in Outpatients With Symptomatic Alcoholic Cirrhosis |
| title_sort | controlled trial on nutrition supplementation in outpatients with symptomatic alcoholic cirrhosis |
| topic | Medicine Parenteral nutrition Internal medicine Gastroenterology Alcoholic liver disease Placebo Cirrhosis Liver disease Randomized controlled trial Alternative medicine Pathology Medicine Parenteral nutrition Internal medicine Gastroenterology Alcoholic liver disease Placebo Cirrhosis Liver disease Randomized controlled trial Adult Adult Adult Ambulatory Care Ambulatory Care Ambulatory Care Enteral Nutrition Enteral Nutrition Enteral Nutrition Female Female Female Humans Humans Humans Liver Cirrhosis, Alcoholic therapy Liver Cirrhosis, Alcoholic therapy Liver Cirrhosis, Alcoholic therapy Male Male Male Middle Aged Middle Aged Middle Aged Time Factors Time Factors Time Factors Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Hepatology Liver Disease and Transplantation |
| topic_facet | Medicine Parenteral nutrition Internal medicine Gastroenterology Alcoholic liver disease Placebo Cirrhosis Liver disease Randomized controlled trial Alternative medicine Pathology Medicine Parenteral nutrition Internal medicine Gastroenterology Alcoholic liver disease Placebo Cirrhosis Liver disease Randomized controlled trial Adult Adult Adult Ambulatory Care Ambulatory Care Ambulatory Care Enteral Nutrition Enteral Nutrition Enteral Nutrition Female Female Female Humans Humans Humans Liver Cirrhosis, Alcoholic therapy Liver Cirrhosis, Alcoholic therapy Liver Cirrhosis, Alcoholic therapy Male Male Male Middle Aged Middle Aged Middle Aged Time Factors Time Factors Time Factors Health Sciences Medicine Epidemiology Liver Disease Diagnosis and Treatment Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Health Sciences Medicine Hepatology Liver Disease and Transplantation |
| url | https://pubmed.ncbi.nlm.nih.gov/8455312 https://hdl.handle.net/20.500.15037/1664 |
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