Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis.
OBJECTIVE: This study was designed to measure the effect of chronic alcohol intake on leucine turnover in outpatients with stable alcoholic liver cirrhosis. METHODS: Protein turnover rate was measured using L [1-14C] leucine in ten outpatients with proven alcoholic cirrhosis and in five healthy cont...
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1995
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| _version_ | 1881508933215977472 |
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| author | Sandra Hirsch María Pía de la Maza Marcus Petermann H Iturriaga G Ugarte Daniel Bunout |
| author_browse | Daniel Bunout G Ugarte H Iturriaga Marcus Petermann María Pía de la Maza Sandra Hirsch |
| author_facet | Sandra Hirsch María Pía de la Maza Marcus Petermann H Iturriaga G Ugarte Daniel Bunout |
| author_sort | Sandra Hirsch |
| collection | Producción científica |
| description | OBJECTIVE: This study was designed to measure the effect of chronic alcohol intake on leucine turnover in outpatients with stable alcoholic liver cirrhosis. METHODS: Protein turnover rate was measured using L [1-14C] leucine in ten outpatients with proven alcoholic cirrhosis and in five healthy controls. After the performance of the turnover, the patients were divided in two groups depending on the evidence of alcohol ingestion in the previous month. RESULTS: Non-abstinent patients had a significantly higher leucine flux and non-oxidative disposal (73.8 +/- 25.4 and 65.9 +/- 21.6) than abstinent cirrhotic patients (48.9 +/- 9.5 and 43.7 +/- 9.0) and normal controls 37.3 +/- 8.9 and 31.1 +/- 7.6 mumol/m2/min (p < 0.01). Leucine oxidation and serum leucine levels were similar in the three groups. CONCLUSION: Alcohol intake in alcoholic cirrhotic patients has a catabolic effect that could be associated with the nutritional imbalances observed in alcoholic liver disease. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1661 |
| institution | UPeU |
| language | English |
| publishDate | 1995 |
| publishDateRange | 1995 |
| publishDateSort | 1995 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/16612026-10-30T16:16:24ZProtein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis.Sandra HirschMaría Pía de la MazaMarcus PetermannH IturriagaG UgarteDaniel BunoutMedicineInternal medicineCirrhosisAlcoholic liver diseaseProtein turnoverGastroenterologyBiologyBiochemistryProtein biosynthesisMedicineInternal medicineCirrhosisAlcoholic liver diseaseProtein turnoverGastroenterologyBiologyBiochemistryProtein biosynthesisAdultAdultAdultEthanol administration & dosageEthanol administration & dosageEthanol administration & dosageHumansHumansHumansKineticsKineticsKineticsLeucine bloodLeucine bloodLeucine bloodLeucine metabolismLeucine metabolismLeucine metabolismLiver Cirrhosis, Alcoholic metabolismLiver Cirrhosis, Alcoholic metabolismLiver Cirrhosis, Alcoholic metabolismMiddle AgedMiddle AgedMiddle AgedOxidation-ReductionOxidation-ReductionOxidation-ReductionProteins metabolismProteins metabolismProteins metabolismHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsLife Sciences Biochemistry, Genetics and Molecular Biology Cell Biology Muscle metabolism and nutritionHealth Sciences Medicine Neurology Alcoholism and Thiamine DeficiencyOBJECTIVE: This study was designed to measure the effect of chronic alcohol intake on leucine turnover in outpatients with stable alcoholic liver cirrhosis. METHODS: Protein turnover rate was measured using L [1-14C] leucine in ten outpatients with proven alcoholic cirrhosis and in five healthy controls. After the performance of the turnover, the patients were divided in two groups depending on the evidence of alcohol ingestion in the previous month. RESULTS: Non-abstinent patients had a significantly higher leucine flux and non-oxidative disposal (73.8 +/- 25.4 and 65.9 +/- 21.6) than abstinent cirrhotic patients (48.9 +/- 9.5 and 43.7 +/- 9.0) and normal controls 37.3 +/- 8.9 and 31.1 +/- 7.6 mumol/m2/min (p < 0.01). Leucine oxidation and serum leucine levels were similar in the three groups. CONCLUSION: Alcohol intake in alcoholic cirrhotic patients has a catabolic effect that could be associated with the nutritional imbalances observed in alcoholic liver disease.Articlehttps://pubmed.ncbi.nlm.nih.gov/770661810.1080/07315724.1995.10718479https://hdl.handle.net/20.500.15037/1661W2040330527enJournal of the American College of Nutrition0731-57241541-10871995-02-012026-06-13T14:18:05Z2026-06-13T14:18:05Z |
| spellingShingle | Medicine Internal medicine Cirrhosis Alcoholic liver disease Protein turnover Gastroenterology Biology Biochemistry Protein biosynthesis Medicine Internal medicine Cirrhosis Alcoholic liver disease Protein turnover Gastroenterology Biology Biochemistry Protein biosynthesis Adult Adult Adult Ethanol administration & dosage Ethanol administration & dosage Ethanol administration & dosage Humans Humans Humans Kinetics Kinetics Kinetics Leucine blood Leucine blood Leucine blood Leucine metabolism Leucine metabolism Leucine metabolism Liver Cirrhosis, Alcoholic metabolism Liver Cirrhosis, Alcoholic metabolism Liver Cirrhosis, Alcoholic metabolism Middle Aged Middle Aged Middle Aged Oxidation-Reduction Oxidation-Reduction Oxidation-Reduction Proteins metabolism Proteins metabolism Proteins metabolism Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology Muscle metabolism and nutrition Health Sciences Medicine Neurology Alcoholism and Thiamine Deficiency Sandra Hirsch María Pía de la Maza Marcus Petermann H Iturriaga G Ugarte Daniel Bunout Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis. |
| title | Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis. |
| title_full | Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis. |
| title_fullStr | Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis. |
| title_full_unstemmed | Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis. |
| title_short | Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis. |
| title_sort | protein turnover in abstinent and non abstinent patients with alcoholic cirrhosis |
| topic | Medicine Internal medicine Cirrhosis Alcoholic liver disease Protein turnover Gastroenterology Biology Biochemistry Protein biosynthesis Medicine Internal medicine Cirrhosis Alcoholic liver disease Protein turnover Gastroenterology Biology Biochemistry Protein biosynthesis Adult Adult Adult Ethanol administration & dosage Ethanol administration & dosage Ethanol administration & dosage Humans Humans Humans Kinetics Kinetics Kinetics Leucine blood Leucine blood Leucine blood Leucine metabolism Leucine metabolism Leucine metabolism Liver Cirrhosis, Alcoholic metabolism Liver Cirrhosis, Alcoholic metabolism Liver Cirrhosis, Alcoholic metabolism Middle Aged Middle Aged Middle Aged Oxidation-Reduction Oxidation-Reduction Oxidation-Reduction Proteins metabolism Proteins metabolism Proteins metabolism Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology Muscle metabolism and nutrition Health Sciences Medicine Neurology Alcoholism and Thiamine Deficiency |
| topic_facet | Medicine Internal medicine Cirrhosis Alcoholic liver disease Protein turnover Gastroenterology Biology Biochemistry Protein biosynthesis Medicine Internal medicine Cirrhosis Alcoholic liver disease Protein turnover Gastroenterology Biology Biochemistry Protein biosynthesis Adult Adult Adult Ethanol administration & dosage Ethanol administration & dosage Ethanol administration & dosage Humans Humans Humans Kinetics Kinetics Kinetics Leucine blood Leucine blood Leucine blood Leucine metabolism Leucine metabolism Leucine metabolism Liver Cirrhosis, Alcoholic metabolism Liver Cirrhosis, Alcoholic metabolism Liver Cirrhosis, Alcoholic metabolism Middle Aged Middle Aged Middle Aged Oxidation-Reduction Oxidation-Reduction Oxidation-Reduction Proteins metabolism Proteins metabolism Proteins metabolism Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology Muscle metabolism and nutrition Health Sciences Medicine Neurology Alcoholism and Thiamine Deficiency |
| url | https://pubmed.ncbi.nlm.nih.gov/7706618 https://hdl.handle.net/20.500.15037/1661 |
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