Effect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial Function
Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes...
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2008
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| _version_ | 1881508963262922752 |
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| author | Marcus Petermann M. Bravo L. V iacute dela G Ugarte |
| author_browse | G Ugarte L. V iacute dela M. Bravo Marcus Petermann |
| author_facet | Marcus Petermann M. Bravo L. V iacute dela G Ugarte |
| author_sort | Marcus Petermann |
| collection | Producción científica |
| description | Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial respiratory functions. Epinephrine given acutely did not modify the rate of ethanol metabolism. Blood glucose levels were enhanced in these conditions, but were unaffected in rats treated with epinephrine plus alprenolol. These results suggest that chronic epinephrine treatment induces an increased oxidative capacity in the liver characterized by enhanced rates of oxygen uptake and ethanol metabolism, which is not related to its beta-adrenergic actions. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1656 |
| institution | UPeU |
| language | English |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/16562026-10-30T16:16:23ZEffect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial FunctionMarcus PetermannM. BravoL. V iacute delaG UgarteAlprenololEpinephrineEndocrinologyInternal medicineMetabolismEthanolAdrenergicChemistryCellular respirationRespirationMitochondrionMedicineReceptorBiochemistryAnatomyAlprenololEpinephrineEndocrinologyInternal medicineMetabolismEthanolAdrenergicChemistryCellular respirationRespirationMitochondrionMedicineReceptorBiochemistryEthanol metabolismEthanol metabolismEthanol metabolismAlprenolol pharmacologyAlprenolol pharmacologyAlprenolol pharmacologyAnimalsAnimalsAnimalsBlood Glucose analysisBlood Glucose analysisBlood Glucose analysisEpinephrine pharmacologyEpinephrine pharmacologyEpinephrine pharmacologyLiver metabolismLiver metabolismLiver metabolismMaleMaleMaleMitochondria, Liver metabolismMitochondria, Liver metabolismMitochondria, Liver metabolismOxygen Consumption drug effectsOxygen Consumption drug effectsOxygen Consumption drug effectsRatsRatsRatsLife Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Peroxisome Proliferator-Activated ReceptorsLife Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension PharmacologyHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsChronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial respiratory functions. Epinephrine given acutely did not modify the rate of ethanol metabolism. Blood glucose levels were enhanced in these conditions, but were unaffected in rats treated with epinephrine plus alprenolol. These results suggest that chronic epinephrine treatment induces an increased oxidative capacity in the liver characterized by enhanced rates of oxygen uptake and ethanol metabolism, which is not related to its beta-adrenergic actions.Articlehttps://pubmed.ncbi.nlm.nih.gov/419160https://repositorio.uchile.cl/handle/2250/16234210.1159/000137228https://hdl.handle.net/20.500.15037/1656W1985629035enPharmacology0031-70121423-03132008-05-292026-06-13T14:17:57Z2026-06-13T14:17:57Z |
| spellingShingle | Alprenolol Epinephrine Endocrinology Internal medicine Metabolism Ethanol Adrenergic Chemistry Cellular respiration Respiration Mitochondrion Medicine Receptor Biochemistry Anatomy Alprenolol Epinephrine Endocrinology Internal medicine Metabolism Ethanol Adrenergic Chemistry Cellular respiration Respiration Mitochondrion Medicine Receptor Biochemistry Ethanol metabolism Ethanol metabolism Ethanol metabolism Alprenolol pharmacology Alprenolol pharmacology Alprenolol pharmacology Animals Animals Animals Blood Glucose analysis Blood Glucose analysis Blood Glucose analysis Epinephrine pharmacology Epinephrine pharmacology Epinephrine pharmacology Liver metabolism Liver metabolism Liver metabolism Male Male Male Mitochondria, Liver metabolism Mitochondria, Liver metabolism Mitochondria, Liver metabolism Oxygen Consumption drug effects Oxygen Consumption drug effects Oxygen Consumption drug effects Rats Rats Rats Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Peroxisome Proliferator-Activated Receptors Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Marcus Petermann M. Bravo L. V iacute dela G Ugarte Effect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial Function |
| title | Effect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial Function |
| title_full | Effect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial Function |
| title_fullStr | Effect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial Function |
| title_full_unstemmed | Effect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial Function |
| title_short | Effect of Epinephrine and Alprenolol on Ethanol Metabolism, Liver Cell Respiration and Mitochondrial Function |
| title_sort | effect of epinephrine and alprenolol on ethanol metabolism liver cell respiration and mitochondrial function |
| topic | Alprenolol Epinephrine Endocrinology Internal medicine Metabolism Ethanol Adrenergic Chemistry Cellular respiration Respiration Mitochondrion Medicine Receptor Biochemistry Anatomy Alprenolol Epinephrine Endocrinology Internal medicine Metabolism Ethanol Adrenergic Chemistry Cellular respiration Respiration Mitochondrion Medicine Receptor Biochemistry Ethanol metabolism Ethanol metabolism Ethanol metabolism Alprenolol pharmacology Alprenolol pharmacology Alprenolol pharmacology Animals Animals Animals Blood Glucose analysis Blood Glucose analysis Blood Glucose analysis Epinephrine pharmacology Epinephrine pharmacology Epinephrine pharmacology Liver metabolism Liver metabolism Liver metabolism Male Male Male Mitochondria, Liver metabolism Mitochondria, Liver metabolism Mitochondria, Liver metabolism Oxygen Consumption drug effects Oxygen Consumption drug effects Oxygen Consumption drug effects Rats Rats Rats Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Peroxisome Proliferator-Activated Receptors Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects |
| topic_facet | Alprenolol Epinephrine Endocrinology Internal medicine Metabolism Ethanol Adrenergic Chemistry Cellular respiration Respiration Mitochondrion Medicine Receptor Biochemistry Anatomy Alprenolol Epinephrine Endocrinology Internal medicine Metabolism Ethanol Adrenergic Chemistry Cellular respiration Respiration Mitochondrion Medicine Receptor Biochemistry Ethanol metabolism Ethanol metabolism Ethanol metabolism Alprenolol pharmacology Alprenolol pharmacology Alprenolol pharmacology Animals Animals Animals Blood Glucose analysis Blood Glucose analysis Blood Glucose analysis Epinephrine pharmacology Epinephrine pharmacology Epinephrine pharmacology Liver metabolism Liver metabolism Liver metabolism Male Male Male Mitochondria, Liver metabolism Mitochondria, Liver metabolism Mitochondria, Liver metabolism Oxygen Consumption drug effects Oxygen Consumption drug effects Oxygen Consumption drug effects Rats Rats Rats Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Peroxisome Proliferator-Activated Receptors Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects |
| url | https://pubmed.ncbi.nlm.nih.gov/419160 https://repositorio.uchile.cl/handle/2250/162342 https://hdl.handle.net/20.500.15037/1656 |
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