Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat
Acute ethanol administration to rats fasted overnight resulted in a significant decrease in the content of glutathione (GSH) of the liver concomitantly with a partial increase in oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. In these conditions, liver lipoper...
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2008
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| author | Luis A. Videla V. Fern aacute ndez A. Valenzuela G Ugarte |
| author_browse | A. Valenzuela G Ugarte Luis A. Videla V. Fern aacute ndez |
| author_facet | Luis A. Videla V. Fern aacute ndez A. Valenzuela G Ugarte |
| author_sort | Luis A. Videla |
| collection | Producción científica |
| description | Acute ethanol administration to rats fasted overnight resulted in a significant decrease in the content of glutathione (GSH) of the liver concomitantly with a partial increase in oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. In these conditions, liver lipoperoxidation is significantly enhanced. Treatment with (+)-cyanidanol-3 prior to ethanol ingestion was able to reduce by 80% the ethanol-induced depletion in total GSH equivalents and to completely abolish lipoperoxidation. These results indicate that (+)-cyanidanol-3 has a protective effect on the changes in liver GSH levels and lipoperoxidation induced by ethanol, probably related to its scavenging action exerted on free radicals. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1655 |
| institution | UPeU |
| language | English |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/16552026-10-30T16:16:23ZEffect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the RatLuis A. VidelaV. Fern aacute ndezA. ValenzuelaG UgarteGlutathioneChemistryEthanolIngestionAntioxidantEndocrinologyInternal medicineLiver injuryPharmacologyBiochemistryMedicineEnzymeGlutathioneChemistryEthanolIngestionAntioxidantEndocrinologyInternal medicineLiver injuryPharmacologyBiochemistryMedicineEnzymeEthanol pharmacologyEthanol pharmacologyEthanol pharmacologyAnimalsAnimalsAnimalsBenzopyrans pharmacologyBenzopyrans pharmacologyBenzopyrans pharmacologyCatechin pharmacologyCatechin pharmacologyCatechin pharmacologyGlucose metabolismGlucose metabolismGlucose metabolismGlutathione metabolismGlutathione metabolismGlutathione metabolismLipid Peroxides metabolismLipid Peroxides metabolismLipid Peroxides metabolismLiver drug effectsLiver drug effectsLiver drug effectsLiver metabolismLiver metabolismLiver metabolismMaleMaleMaleRatsRatsRatsLife Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension PharmacologyHealth Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health EffectsLife Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in BiologyAcute ethanol administration to rats fasted overnight resulted in a significant decrease in the content of glutathione (GSH) of the liver concomitantly with a partial increase in oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. In these conditions, liver lipoperoxidation is significantly enhanced. Treatment with (+)-cyanidanol-3 prior to ethanol ingestion was able to reduce by 80% the ethanol-induced depletion in total GSH equivalents and to completely abolish lipoperoxidation. These results indicate that (+)-cyanidanol-3 has a protective effect on the changes in liver GSH levels and lipoperoxidation induced by ethanol, probably related to its scavenging action exerted on free radicals.Articlehttps://pubmed.ncbi.nlm.nih.gov/7267700http://repositorio.uchile.cl/handle/2250/16041010.1159/000137514https://hdl.handle.net/20.500.15037/1655W2040923359enPharmacology0031-70121423-03132008-05-302026-06-13T14:17:55Z2026-06-13T14:17:55Z |
| spellingShingle | Glutathione Chemistry Ethanol Ingestion Antioxidant Endocrinology Internal medicine Liver injury Pharmacology Biochemistry Medicine Enzyme Glutathione Chemistry Ethanol Ingestion Antioxidant Endocrinology Internal medicine Liver injury Pharmacology Biochemistry Medicine Enzyme Ethanol pharmacology Ethanol pharmacology Ethanol pharmacology Animals Animals Animals Benzopyrans pharmacology Benzopyrans pharmacology Benzopyrans pharmacology Catechin pharmacology Catechin pharmacology Catechin pharmacology Glucose metabolism Glucose metabolism Glucose metabolism Glutathione metabolism Glutathione metabolism Glutathione metabolism Lipid Peroxides metabolism Lipid Peroxides metabolism Lipid Peroxides metabolism Liver drug effects Liver drug effects Liver drug effects Liver metabolism Liver metabolism Liver metabolism Male Male Male Rats Rats Rats Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in Biology Luis A. Videla V. Fern aacute ndez A. Valenzuela G Ugarte Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat |
| title | Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat |
| title_full | Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat |
| title_fullStr | Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat |
| title_full_unstemmed | Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat |
| title_short | Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat |
| title_sort | effect of cyanidanol 3 on the changes in liver glutathione content and lipoperoxidation induced by acute ethanol administration in the rat |
| topic | Glutathione Chemistry Ethanol Ingestion Antioxidant Endocrinology Internal medicine Liver injury Pharmacology Biochemistry Medicine Enzyme Glutathione Chemistry Ethanol Ingestion Antioxidant Endocrinology Internal medicine Liver injury Pharmacology Biochemistry Medicine Enzyme Ethanol pharmacology Ethanol pharmacology Ethanol pharmacology Animals Animals Animals Benzopyrans pharmacology Benzopyrans pharmacology Benzopyrans pharmacology Catechin pharmacology Catechin pharmacology Catechin pharmacology Glucose metabolism Glucose metabolism Glucose metabolism Glutathione metabolism Glutathione metabolism Glutathione metabolism Lipid Peroxides metabolism Lipid Peroxides metabolism Lipid Peroxides metabolism Liver drug effects Liver drug effects Liver drug effects Liver metabolism Liver metabolism Liver metabolism Male Male Male Rats Rats Rats Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in Biology |
| topic_facet | Glutathione Chemistry Ethanol Ingestion Antioxidant Endocrinology Internal medicine Liver injury Pharmacology Biochemistry Medicine Enzyme Glutathione Chemistry Ethanol Ingestion Antioxidant Endocrinology Internal medicine Liver injury Pharmacology Biochemistry Medicine Enzyme Ethanol pharmacology Ethanol pharmacology Ethanol pharmacology Animals Animals Animals Benzopyrans pharmacology Benzopyrans pharmacology Benzopyrans pharmacology Catechin pharmacology Catechin pharmacology Catechin pharmacology Glucose metabolism Glucose metabolism Glucose metabolism Glutathione metabolism Glutathione metabolism Glutathione metabolism Lipid Peroxides metabolism Lipid Peroxides metabolism Lipid Peroxides metabolism Liver drug effects Liver drug effects Liver drug effects Liver metabolism Liver metabolism Liver metabolism Male Male Male Rats Rats Rats Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Eicosanoids and Hypertension Pharmacology Health Sciences Medicine Pathology and Forensic Medicine Alcohol Consumption and Health Effects Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry Sulfur Compounds in Biology |
| url | https://pubmed.ncbi.nlm.nih.gov/7267700 http://repositorio.uchile.cl/handle/2250/160410 https://hdl.handle.net/20.500.15037/1655 |
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