Immune responses in COVID-19 and tuberculosis coinfection: A scoping review
Background and aim: Patients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfection. Methods: We searched Pubmed/MEDLINE, EMBASE,...
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| Autores principales: | , , , , , , , |
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| Lenguaje: | inglés |
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2022
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| _version_ | 1881508957365731328 |
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| author | Flores-Lovon, Kevin Ortiz-Saavedra, Brando Cueva-Chicaña, Luis A. Aperrigue-Lira, Shalom Montes-Madariaga, Elizbet S. Soriano‐Moreno, David R. Bell, Brett Macedo, Rodney |
| author_browse | Aperrigue-Lira, Shalom Bell, Brett Cueva-Chicaña, Luis A. Flores-Lovon, Kevin Macedo, Rodney Montes-Madariaga, Elizbet S. Ortiz-Saavedra, Brando Soriano‐Moreno, David R. |
| author_facet | Flores-Lovon, Kevin Ortiz-Saavedra, Brando Cueva-Chicaña, Luis A. Aperrigue-Lira, Shalom Montes-Madariaga, Elizbet S. Soriano‐Moreno, David R. Bell, Brett Macedo, Rodney |
| author_sort | Flores-Lovon, Kevin |
| collection | Producción científica |
| description | Background and aim: Patients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfection. Methods: We searched Pubmed/MEDLINE, EMBASE, Scopus, and Web of Science to identify articles published between 2020 and 2021. We included observational studies evaluating the immune response in patients with tuberculosis and COVID-19 compared to patients with COVID-19 alone. Results: Four cross-sectional studies (372 participants) were identified. In patients with asymptomatic COVID-19 and latent tuberculosis (LTBI), increased cytokines, chemokines, growth factors and humoral responses were found. In addition, patients with symptomatic COVID-19 and LTBI had higher leukocytes counts and less inflammation. Regarding patients with COVID-19 and active tuberculosis (aTB), they exhibited decreased total lymphocyte counts, CD4 T cells specific against SARS-CoV-2 and responsiveness to SARS-CoV-2 antigens compared to patients with only COVID-19. Conclusion: Although the evidence is limited, an apparent positive immunomodulation is observed in patients with COVID-19 and LTBI. On the other hand, patients with COVID-19 and aTB present a dysregulated immune response. Longitudinal studies are needed to confirm these findings and expand knowledge. |
| format | Other |
| id | oai:cris.upeu.edu.pe:20.500.15037/1515 |
| institution | UPeU |
| language | English |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/15152026-10-30T16:16:01ZImmune responses in COVID-19 and tuberculosis coinfection: A scoping reviewFlores-Lovon, KevinOrtiz-Saavedra, BrandoCueva-Chicaña, Luis A.Aperrigue-Lira, ShalomMontes-Madariaga, Elizbet S.Soriano‐Moreno, David R.Bell, BrettMacedo, RodneyCoinfectionMedicineTuberculosisImmune systemImmunologyAsymptomaticMycobacterium tuberculosisLatent tuberculosisCoronavirus disease 2019 (COVID-19)DiseaseInternal medicineVirusInfectious disease (medical specialty)PathologyCOVID-19SARS-CoV-2Cross-Sectional StudiesHumansImmunityHealth Sciences Medicine Infectious Diseases COVID-19 Clinical Research StudiesLife Sciences Immunology and Microbiology Immunology Immune responses and vaccinationsHealth Sciences Medicine Neurology Long-Term Effects of COVID-19Background and aim: Patients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfection. Methods: We searched Pubmed/MEDLINE, EMBASE, Scopus, and Web of Science to identify articles published between 2020 and 2021. We included observational studies evaluating the immune response in patients with tuberculosis and COVID-19 compared to patients with COVID-19 alone. Results: Four cross-sectional studies (372 participants) were identified. In patients with asymptomatic COVID-19 and latent tuberculosis (LTBI), increased cytokines, chemokines, growth factors and humoral responses were found. In addition, patients with symptomatic COVID-19 and LTBI had higher leukocytes counts and less inflammation. Regarding patients with COVID-19 and active tuberculosis (aTB), they exhibited decreased total lymphocyte counts, CD4 T cells specific against SARS-CoV-2 and responsiveness to SARS-CoV-2 antigens compared to patients with only COVID-19. Conclusion: Although the evidence is limited, an apparent positive immunomodulation is observed in patients with COVID-19 and LTBI. On the other hand, patients with COVID-19 and aTB present a dysregulated immune response. Longitudinal studies are needed to confirm these findings and expand knowledge.Otherhttps://pubmed.ncbi.nlm.nih.gov/36090983https://www.frontiersin.org/articles/10.3389/fimmu.2022.992743/pdfhttps://doi.org/10.3389/fimmu.2022.99274310.3389/fimmu.2022.992743https://hdl.handle.net/20.500.15037/1515W4293109488enFrontiers in Immunology1664-32242022-08-262026-06-13T13:21:39Z2026-06-13T13:21:39Z |
| spellingShingle | Coinfection Medicine Tuberculosis Immune system Immunology Asymptomatic Mycobacterium tuberculosis Latent tuberculosis Coronavirus disease 2019 (COVID-19) Disease Internal medicine Virus Infectious disease (medical specialty) Pathology COVID-19 SARS-CoV-2 Cross-Sectional Studies Humans Immunity Health Sciences Medicine Infectious Diseases COVID-19 Clinical Research Studies Life Sciences Immunology and Microbiology Immunology Immune responses and vaccinations Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Flores-Lovon, Kevin Ortiz-Saavedra, Brando Cueva-Chicaña, Luis A. Aperrigue-Lira, Shalom Montes-Madariaga, Elizbet S. Soriano‐Moreno, David R. Bell, Brett Macedo, Rodney Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_full | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_fullStr | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_full_unstemmed | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_short | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_sort | immune responses in covid 19 and tuberculosis coinfection a scoping review |
| topic | Coinfection Medicine Tuberculosis Immune system Immunology Asymptomatic Mycobacterium tuberculosis Latent tuberculosis Coronavirus disease 2019 (COVID-19) Disease Internal medicine Virus Infectious disease (medical specialty) Pathology COVID-19 SARS-CoV-2 Cross-Sectional Studies Humans Immunity Health Sciences Medicine Infectious Diseases COVID-19 Clinical Research Studies Life Sciences Immunology and Microbiology Immunology Immune responses and vaccinations Health Sciences Medicine Neurology Long-Term Effects of COVID-19 |
| topic_facet | Coinfection Medicine Tuberculosis Immune system Immunology Asymptomatic Mycobacterium tuberculosis Latent tuberculosis Coronavirus disease 2019 (COVID-19) Disease Internal medicine Virus Infectious disease (medical specialty) Pathology COVID-19 SARS-CoV-2 Cross-Sectional Studies Humans Immunity Health Sciences Medicine Infectious Diseases COVID-19 Clinical Research Studies Life Sciences Immunology and Microbiology Immunology Immune responses and vaccinations Health Sciences Medicine Neurology Long-Term Effects of COVID-19 |
| url | https://pubmed.ncbi.nlm.nih.gov/36090983 https://www.frontiersin.org/articles/10.3389/fimmu.2022.992743/pdf https://doi.org/10.3389/fimmu.2022.992743 https://hdl.handle.net/20.500.15037/1515 |
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