Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening
BACKGROUND: Persistent HPV infection causes cervical cancer, but most infections are transient. Triage methods identify high-risk women needing further evaluation or treatment. We assessed short-term repeat HPV testing as an alternative triage option. METHODS: In ESTAMPA, women aged 30-64 years were...
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| author | Armando Baena Marı́a Alejandra Picconi Laura Mendoza Annabelle Ferrera David Mesher Johana Lineros Marisol Brizuela Pamela Mongelós Yessy Cabrera Marı́a Dolores Fellner Osmalia Zambrana Laura García Pilar Hernández María Liz Bobadilla María Antonia Ramón Gino Venegas Rodríguez Verónica Villagra Aurelio Cruz-Valdéz Guillermo Rodríguez‐Domínguez Carolina Terán Alejandro Calderón Carolina Wiesner Rolando Herrero Maribel Almonte on behalf of the ESTAMPA study group Yenny Bellido‐Fuentes Andrea Verónica Beracochea María Celeste Colucci Rita Mariel Correa Jacqueline Figueroa Bettsy Flores Diana Gimenez María de la Luz Hernández Elena Kasamatsu Victoria Murillo Marina Ortega Natalia Pérez Rolando Pinastel Monet Arianis Tatiana Ramírez Maria Isabel Rodríguez Mercedes Rodríguez de la Peña Yuli Salgado Ana Soilán Charles Quesada |
| author_browse | Alejandro Calderón Ana Soilán Andrea Verónica Beracochea Annabelle Ferrera Arianis Tatiana Ramírez Armando Baena Aurelio Cruz-Valdéz Bettsy Flores Carolina Terán Carolina Wiesner Charles Quesada David Mesher Diana Gimenez Elena Kasamatsu Gino Venegas Rodríguez Guillermo Rodríguez‐Domínguez Jacqueline Figueroa Johana Lineros Laura García Laura Mendoza Maria Isabel Rodríguez Maribel Almonte Marina Ortega Marisol Brizuela María Antonia Ramón María Celeste Colucci María Liz Bobadilla María de la Luz Hernández Marı́a Alejandra Picconi Marı́a Dolores Fellner Mercedes Rodríguez de la Peña Natalia Pérez Osmalia Zambrana Pamela Mongelós Pilar Hernández Rita Mariel Correa Rolando Herrero Rolando Pinastel Monet Verónica Villagra Victoria Murillo Yenny Bellido‐Fuentes Yessy Cabrera Yuli Salgado on behalf of the ESTAMPA study group |
| author_facet | Armando Baena Marı́a Alejandra Picconi Laura Mendoza Annabelle Ferrera David Mesher Johana Lineros Marisol Brizuela Pamela Mongelós Yessy Cabrera Marı́a Dolores Fellner Osmalia Zambrana Laura García Pilar Hernández María Liz Bobadilla María Antonia Ramón Gino Venegas Rodríguez Verónica Villagra Aurelio Cruz-Valdéz Guillermo Rodríguez‐Domínguez Carolina Terán Alejandro Calderón Carolina Wiesner Rolando Herrero Maribel Almonte on behalf of the ESTAMPA study group Yenny Bellido‐Fuentes Andrea Verónica Beracochea María Celeste Colucci Rita Mariel Correa Jacqueline Figueroa Bettsy Flores Diana Gimenez María de la Luz Hernández Elena Kasamatsu Victoria Murillo Marina Ortega Natalia Pérez Rolando Pinastel Monet Arianis Tatiana Ramírez Maria Isabel Rodríguez Mercedes Rodríguez de la Peña Yuli Salgado Ana Soilán Charles Quesada |
| author_sort | Armando Baena |
| collection | Producción científica |
| description | BACKGROUND: Persistent HPV infection causes cervical cancer, but most infections are transient. Triage methods identify high-risk women needing further evaluation or treatment. We assessed short-term repeat HPV testing as an alternative triage option. METHODS: In ESTAMPA, women aged 30-64 years were screened with HPV testing (HC2 or Cobas) and cytology. Screen positives were referred to colposcopy approximately two months after screening, where cervical samples were collected again for repeat HPV testing. We evaluated the performance of repeat HPV for CIN3+ among HPV-positive women and explored its combination with limited HPV genotyping (HPV16/18). RESULTS: Among 5390 HPV-positive women (including 629 CIN3 cases and 53 cancers), 61% retested positive at ~2 months (median: 1.8, interquartile range: 1.2-2.8). Repeat HPV sensitivity for CIN3+ was 81.5% (95% CI 77.2-85.2) for HC2 and 87.7% (83.7-90.8) for Cobas. Specificity was <50% with referral rates of 57.4% (55.7-59.0) and 68.2% (66.1-70.2) for HC2 and Cobas. HPV16/18 genotyping followed by repeat HPV among non-HPV16/18-positive women did not greatly improve performance. However, HPV16/18 positivity doubled the risk of CIN3+, supporting its combination with repeat HPV when available. CONCLUSIONS: Short-term repeat HPV testing could be a practical option for triaging HPV-positive women, either alone or in combination with limited HPV genotyping. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01881659. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1347 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/13472026-10-30T16:15:37ZShort-term repeat HPV testing for triaging HPV-positive women in cervical cancer screeningArmando BaenaMarı́a Alejandra PicconiLaura MendozaAnnabelle FerreraDavid MesherJohana LinerosMarisol BrizuelaPamela MongelósYessy CabreraMarı́a Dolores FellnerOsmalia ZambranaLaura GarcíaPilar HernándezMaría Liz BobadillaMaría Antonia RamónGino Venegas RodríguezVerónica VillagraAurelio Cruz-ValdézGuillermo Rodríguez‐DomínguezCarolina TeránAlejandro CalderónCarolina WiesnerRolando HerreroMaribel Almonteon behalf of the ESTAMPA study groupYenny Bellido‐FuentesAndrea Verónica BeracocheaMaría Celeste ColucciRita Mariel CorreaJacqueline FigueroaBettsy FloresDiana GimenezMaría de la Luz HernándezElena KasamatsuVictoria MurilloMarina OrtegaNatalia PérezRolando Pinastel MonetArianis Tatiana RamírezMaria Isabel RodríguezMercedes Rodríguez de la PeñaYuli SalgadoAna SoilánCharles QuesadaMedicineCervical cancer screeningCervical cancerGynecologyOncologyCervical screeningMedical screeningInternal medicineHuman papillomavirusPapillomaviridaeCancer screeningMEDLINEColposcopyUterine cervixPredictive value of testsRetrospective cohort studyEpidemiologyObstetricsCancerCervixRisk assessmentPremalignant lesionScreening testSexually transmitted diseaseCervical intraepithelial neoplasiaYoung adultCervical carcinomaViral diseaseCervical cancer screeningCervical cancerCervical screeningMedical screeningHuman papillomavirusPapillomaviridaeCancer screeningMEDLINEColposcopyAdultAdultAdultAdultUterine Cervical Dysplasia diagnosisUterine Cervical Dysplasia diagnosisUterine Cervical Dysplasia diagnosisUterine Cervical Dysplasia diagnosisUterine Cervical Dysplasia virologyUterine Cervical Dysplasia virologyUterine Cervical Dysplasia virologyUterine Cervical Dysplasia virologyUterine Cervical Neoplasms diagnosisUterine Cervical Neoplasms diagnosisUterine Cervical Neoplasms diagnosisUterine Cervical Neoplasms diagnosisUterine Cervical Neoplasms pathologyUterine Cervical Neoplasms pathologyUterine Cervical Neoplasms pathologyUterine Cervical Neoplasms pathologyUterine Cervical Neoplasms virologyUterine Cervical Neoplasms virologyUterine Cervical Neoplasms virologyUterine Cervical Neoplasms virologyColposcopyColposcopyColposcopyColposcopyFemaleFemaleFemaleFemaleGenotypeGenotypeGenotypeGenotypeHumansHumansHumansHumansMiddle AgedMiddle AgedMiddle AgedMiddle AgedTriage methodsTriage methodsTriage methodsTriage methodsPapillomaviridae geneticsPapillomaviridae geneticsPapillomaviridae geneticsPapillomaviridae geneticsPapillomaviridae isolation & purificationPapillomaviridae isolation & purificationPapillomaviridae isolation & purificationPapillomaviridae isolation & purificationPapillomavirus Infections diagnosisPapillomavirus Infections diagnosisPapillomavirus Infections diagnosisPapillomavirus Infections diagnosisPapillomavirus Infections virologyPapillomavirus Infections virologyPapillomavirus Infections virologyPapillomavirus Infections virologyHuman papillomavirus 18 geneticsHuman papillomavirus 18 geneticsHuman papillomavirus 18 geneticsHuman papillomavirus 18 geneticsHuman papillomavirus 18 isolation & purificationHuman papillomavirus 18 isolation & purificationHuman papillomavirus 18 isolation & purificationHuman papillomavirus 18 isolation & purificationHuman papillomavirus 16 geneticsHuman papillomavirus 16 geneticsHuman papillomavirus 16 geneticsHuman papillomavirus 16 geneticsHuman papillomavirus 16 isolation & purificationHuman papillomavirus 16 isolation & purificationHuman papillomavirus 16 isolation & purificationHuman papillomavirus 16 isolation & purificationEarly Detection of Cancer methodsEarly Detection of Cancer methodsEarly Detection of Cancer methodsEarly Detection of Cancer methodsHealth Sciences Medicine Epidemiology Cervical Cancer and HPV ResearchHealth Sciences Medicine Otorhinolaryngology Head and Neck Cancer StudiesHealth Sciences Medicine Public Health, Environmental and Occupational Health Women's cancer prevention and managementBACKGROUND: Persistent HPV infection causes cervical cancer, but most infections are transient. Triage methods identify high-risk women needing further evaluation or treatment. We assessed short-term repeat HPV testing as an alternative triage option. METHODS: In ESTAMPA, women aged 30-64 years were screened with HPV testing (HC2 or Cobas) and cytology. Screen positives were referred to colposcopy approximately two months after screening, where cervical samples were collected again for repeat HPV testing. We evaluated the performance of repeat HPV for CIN3+ among HPV-positive women and explored its combination with limited HPV genotyping (HPV16/18). RESULTS: Among 5390 HPV-positive women (including 629 CIN3 cases and 53 cancers), 61% retested positive at ~2 months (median: 1.8, interquartile range: 1.2-2.8). Repeat HPV sensitivity for CIN3+ was 81.5% (95% CI 77.2-85.2) for HC2 and 87.7% (83.7-90.8) for Cobas. Specificity was <50% with referral rates of 57.4% (55.7-59.0) and 68.2% (66.1-70.2) for HC2 and Cobas. HPV16/18 genotyping followed by repeat HPV among non-HPV16/18-positive women did not greatly improve performance. However, HPV16/18 positivity doubled the risk of CIN3+, supporting its combination with repeat HPV when available. CONCLUSIONS: Short-term repeat HPV testing could be a practical option for triaging HPV-positive women, either alone or in combination with limited HPV genotyping. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01881659.Articlehttps://pubmed.ncbi.nlm.nih.gov/41044173https://doi.org/10.1038/s41416-025-03193-010.1038/s41416-025-03193-0https://hdl.handle.net/20.500.15037/1347W4414785410enBritish Journal of Cancer0007-09201532-18272025-10-032026-06-13T09:54:18Z2026-06-13T09:54:18Z |
| spellingShingle | Medicine Cervical cancer screening Cervical cancer Gynecology Oncology Cervical screening Medical screening Internal medicine Human papillomavirus Papillomaviridae Cancer screening MEDLINE Colposcopy Uterine cervix Predictive value of tests Retrospective cohort study Epidemiology Obstetrics Cancer Cervix Risk assessment Premalignant lesion Screening test Sexually transmitted disease Cervical intraepithelial neoplasia Young adult Cervical carcinoma Viral disease Cervical cancer screening Cervical cancer Cervical screening Medical screening Human papillomavirus Papillomaviridae Cancer screening MEDLINE Colposcopy Adult Adult Adult Adult Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Colposcopy Colposcopy Colposcopy Colposcopy Female Female Female Female Genotype Genotype Genotype Genotype Humans Humans Humans Humans Middle Aged Middle Aged Middle Aged Middle Aged Triage methods Triage methods Triage methods Triage methods Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections virology Papillomavirus Infections virology Papillomavirus Infections virology Papillomavirus Infections virology Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Early Detection of Cancer methods Early Detection of Cancer methods Early Detection of Cancer methods Early Detection of Cancer methods Health Sciences Medicine Epidemiology Cervical Cancer and HPV Research Health Sciences Medicine Otorhinolaryngology Head and Neck Cancer Studies Health Sciences Medicine Public Health, Environmental and Occupational Health Women's cancer prevention and management Armando Baena Marı́a Alejandra Picconi Laura Mendoza Annabelle Ferrera David Mesher Johana Lineros Marisol Brizuela Pamela Mongelós Yessy Cabrera Marı́a Dolores Fellner Osmalia Zambrana Laura García Pilar Hernández María Liz Bobadilla María Antonia Ramón Gino Venegas Rodríguez Verónica Villagra Aurelio Cruz-Valdéz Guillermo Rodríguez‐Domínguez Carolina Terán Alejandro Calderón Carolina Wiesner Rolando Herrero Maribel Almonte on behalf of the ESTAMPA study group Yenny Bellido‐Fuentes Andrea Verónica Beracochea María Celeste Colucci Rita Mariel Correa Jacqueline Figueroa Bettsy Flores Diana Gimenez María de la Luz Hernández Elena Kasamatsu Victoria Murillo Marina Ortega Natalia Pérez Rolando Pinastel Monet Arianis Tatiana Ramírez Maria Isabel Rodríguez Mercedes Rodríguez de la Peña Yuli Salgado Ana Soilán Charles Quesada Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening |
| title | Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening |
| title_full | Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening |
| title_fullStr | Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening |
| title_full_unstemmed | Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening |
| title_short | Short-term repeat HPV testing for triaging HPV-positive women in cervical cancer screening |
| title_sort | short term repeat hpv testing for triaging hpv positive women in cervical cancer screening |
| topic | Medicine Cervical cancer screening Cervical cancer Gynecology Oncology Cervical screening Medical screening Internal medicine Human papillomavirus Papillomaviridae Cancer screening MEDLINE Colposcopy Uterine cervix Predictive value of tests Retrospective cohort study Epidemiology Obstetrics Cancer Cervix Risk assessment Premalignant lesion Screening test Sexually transmitted disease Cervical intraepithelial neoplasia Young adult Cervical carcinoma Viral disease Cervical cancer screening Cervical cancer Cervical screening Medical screening Human papillomavirus Papillomaviridae Cancer screening MEDLINE Colposcopy Adult Adult Adult Adult Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Colposcopy Colposcopy Colposcopy Colposcopy Female Female Female Female Genotype Genotype Genotype Genotype Humans Humans Humans Humans Middle Aged Middle Aged Middle Aged Middle Aged Triage methods Triage methods Triage methods Triage methods Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections virology Papillomavirus Infections virology Papillomavirus Infections virology Papillomavirus Infections virology Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Early Detection of Cancer methods Early Detection of Cancer methods Early Detection of Cancer methods Early Detection of Cancer methods Health Sciences Medicine Epidemiology Cervical Cancer and HPV Research Health Sciences Medicine Otorhinolaryngology Head and Neck Cancer Studies Health Sciences Medicine Public Health, Environmental and Occupational Health Women's cancer prevention and management |
| topic_facet | Medicine Cervical cancer screening Cervical cancer Gynecology Oncology Cervical screening Medical screening Internal medicine Human papillomavirus Papillomaviridae Cancer screening MEDLINE Colposcopy Uterine cervix Predictive value of tests Retrospective cohort study Epidemiology Obstetrics Cancer Cervix Risk assessment Premalignant lesion Screening test Sexually transmitted disease Cervical intraepithelial neoplasia Young adult Cervical carcinoma Viral disease Cervical cancer screening Cervical cancer Cervical screening Medical screening Human papillomavirus Papillomaviridae Cancer screening MEDLINE Colposcopy Adult Adult Adult Adult Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia diagnosis Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Dysplasia virology Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms diagnosis Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms pathology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Uterine Cervical Neoplasms virology Colposcopy Colposcopy Colposcopy Colposcopy Female Female Female Female Genotype Genotype Genotype Genotype Humans Humans Humans Humans Middle Aged Middle Aged Middle Aged Middle Aged Triage methods Triage methods Triage methods Triage methods Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae genetics Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomaviridae isolation & purification Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections diagnosis Papillomavirus Infections virology Papillomavirus Infections virology Papillomavirus Infections virology Papillomavirus Infections virology Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 genetics Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 18 isolation & purification Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 genetics Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Human papillomavirus 16 isolation & purification Early Detection of Cancer methods Early Detection of Cancer methods Early Detection of Cancer methods Early Detection of Cancer methods Health Sciences Medicine Epidemiology Cervical Cancer and HPV Research Health Sciences Medicine Otorhinolaryngology Head and Neck Cancer Studies Health Sciences Medicine Public Health, Environmental and Occupational Health Women's cancer prevention and management |
| url | https://pubmed.ncbi.nlm.nih.gov/41044173 https://doi.org/10.1038/s41416-025-03193-0 https://hdl.handle.net/20.500.15037/1347 |
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