Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review
Pharmacologic treatment of postoperative pain after cleft palate repair includes opioids and nonopioid analgesics, nerve blocks, and local anesthetic infiltration. Use of opioids in infants has concerns regarding sedation, risk of aspiration, respiratory depression, and respiratory distress. The mai...
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2021
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| author | Percy Rossell‐Perry Carolina Romero-Narváez Ruth Rojas-Sandoval Paula Andrea Gómez-Henao Maria Pia Delgado-Jimenez Renato Marca-Ticona |
| author_browse | Carolina Romero-Narváez Maria Pia Delgado-Jimenez Paula Andrea Gómez-Henao Percy Rossell‐Perry Renato Marca-Ticona Ruth Rojas-Sandoval |
| author_facet | Percy Rossell‐Perry Carolina Romero-Narváez Ruth Rojas-Sandoval Paula Andrea Gómez-Henao Maria Pia Delgado-Jimenez Renato Marca-Ticona |
| author_sort | Percy Rossell‐Perry |
| collection | Producción científica |
| description | Pharmacologic treatment of postoperative pain after cleft palate repair includes opioids and nonopioid analgesics, nerve blocks, and local anesthetic infiltration. Use of opioids in infants has concerns regarding sedation, risk of aspiration, respiratory depression, and respiratory distress. The main objective of this review was to analyze information available on the safety of the use of opioids during perioperative management of pain related to primary cleft palate repair in published studies. METHODS: A systematic review of the literature for studies published until March 2020 was performed to evaluate the safety of opioid drugs during primary cleft palate repair pain management. The authors chose the following MesH terms for this systematic review: cleft lip and palate AND opioids AND pain management. The investigators performed a systematic literature search using the Pubmed/MEDLINE, Embase, Web of Science, and Cochrane Library databases. RESULTS: After a literature search resulting in 70 identified studies, 9 were qualified for the final analysis, which included 772 patients. There was a high level of evidence in the selected studies according to the Oxford CEBM Level of Evidence classification and GRADE scale. The most common adverse event reported was postoperative nausea and vomiting (from 5% to 25%). Episodes of oxygen desaturation have been reported from 2.5% to 7.4% of the studied patients. CONCLUSION: s: Definitive conclusions about the safety of opioid drugs during primary cleft palate repair pain management cannot be drawn. Vomiting and oxygen desaturation have been associated with the use of opioids in the studied population. |
| format | Other |
| id | oai:cris.upeu.edu.pe:20.500.15037/1299 |
| institution | UPeU |
| language | English |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/12992026-10-30T16:15:32ZIs the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic ReviewPercy Rossell‐PerryCarolina Romero-NarváezRuth Rojas-SandovalPaula Andrea Gómez-HenaoMaria Pia Delgado-JimenezRenato Marca-TiconaMedicineCochrane LibraryPerioperativeSystematic reviewNauseaOpioidAdverse effectVomitingSedationRespiratory distressAnesthesiaMEDLINEPopulationSurgeryInternal medicineRandomized controlled trialEnvironmental healthPolitical scienceReceptorLawMedicineCochrane LibraryPerioperativeSystematic reviewNauseaOpioidAdverse effectVomitingSedationRespiratory distressAnesthesiaMEDLINEPopulationSurgeryInternal medicineRandomized controlled trialLife Sciences Biochemistry, Genetics and Molecular Biology Genetics Cleft Lip and Palate ResearchHealth Sciences Medicine Surgery Anesthesia and Pain ManagementLife Sciences Neuroscience Developmental Neuroscience Anesthesia and Neurotoxicity ResearchPharmacologic treatment of postoperative pain after cleft palate repair includes opioids and nonopioid analgesics, nerve blocks, and local anesthetic infiltration. Use of opioids in infants has concerns regarding sedation, risk of aspiration, respiratory depression, and respiratory distress. The main objective of this review was to analyze information available on the safety of the use of opioids during perioperative management of pain related to primary cleft palate repair in published studies. METHODS: A systematic review of the literature for studies published until March 2020 was performed to evaluate the safety of opioid drugs during primary cleft palate repair pain management. The authors chose the following MesH terms for this systematic review: cleft lip and palate AND opioids AND pain management. The investigators performed a systematic literature search using the Pubmed/MEDLINE, Embase, Web of Science, and Cochrane Library databases. RESULTS: After a literature search resulting in 70 identified studies, 9 were qualified for the final analysis, which included 772 patients. There was a high level of evidence in the selected studies according to the Oxford CEBM Level of Evidence classification and GRADE scale. The most common adverse event reported was postoperative nausea and vomiting (from 5% to 25%). Episodes of oxygen desaturation have been reported from 2.5% to 7.4% of the studied patients. CONCLUSION: s: Definitive conclusions about the safety of opioid drugs during primary cleft palate repair pain management cannot be drawn. Vomiting and oxygen desaturation have been associated with the use of opioids in the studied population.Otherhttps://pubmed.ncbi.nlm.nih.gov/33564585https://doi.org/10.1097/gox.000000000000335510.1097/gox.0000000000003355https://hdl.handle.net/20.500.15037/1299W3124838687enPlastic & Reconstructive Surgery Global Open2169-75742021-01-012026-06-13T09:52:42Z2026-06-13T09:52:42Z |
| spellingShingle | Medicine Cochrane Library Perioperative Systematic review Nausea Opioid Adverse effect Vomiting Sedation Respiratory distress Anesthesia MEDLINE Population Surgery Internal medicine Randomized controlled trial Environmental health Political science Receptor Law Medicine Cochrane Library Perioperative Systematic review Nausea Opioid Adverse effect Vomiting Sedation Respiratory distress Anesthesia MEDLINE Population Surgery Internal medicine Randomized controlled trial Life Sciences Biochemistry, Genetics and Molecular Biology Genetics Cleft Lip and Palate Research Health Sciences Medicine Surgery Anesthesia and Pain Management Life Sciences Neuroscience Developmental Neuroscience Anesthesia and Neurotoxicity Research Percy Rossell‐Perry Carolina Romero-Narváez Ruth Rojas-Sandoval Paula Andrea Gómez-Henao Maria Pia Delgado-Jimenez Renato Marca-Ticona Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review |
| title | Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review |
| title_full | Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review |
| title_fullStr | Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review |
| title_full_unstemmed | Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review |
| title_short | Is the Use of Opioids Safe after Primary Cleft Palate Repair? A Systematic Review |
| title_sort | is the use of opioids safe after primary cleft palate repair a systematic review |
| topic | Medicine Cochrane Library Perioperative Systematic review Nausea Opioid Adverse effect Vomiting Sedation Respiratory distress Anesthesia MEDLINE Population Surgery Internal medicine Randomized controlled trial Environmental health Political science Receptor Law Medicine Cochrane Library Perioperative Systematic review Nausea Opioid Adverse effect Vomiting Sedation Respiratory distress Anesthesia MEDLINE Population Surgery Internal medicine Randomized controlled trial Life Sciences Biochemistry, Genetics and Molecular Biology Genetics Cleft Lip and Palate Research Health Sciences Medicine Surgery Anesthesia and Pain Management Life Sciences Neuroscience Developmental Neuroscience Anesthesia and Neurotoxicity Research |
| topic_facet | Medicine Cochrane Library Perioperative Systematic review Nausea Opioid Adverse effect Vomiting Sedation Respiratory distress Anesthesia MEDLINE Population Surgery Internal medicine Randomized controlled trial Environmental health Political science Receptor Law Medicine Cochrane Library Perioperative Systematic review Nausea Opioid Adverse effect Vomiting Sedation Respiratory distress Anesthesia MEDLINE Population Surgery Internal medicine Randomized controlled trial Life Sciences Biochemistry, Genetics and Molecular Biology Genetics Cleft Lip and Palate Research Health Sciences Medicine Surgery Anesthesia and Pain Management Life Sciences Neuroscience Developmental Neuroscience Anesthesia and Neurotoxicity Research |
| url | https://pubmed.ncbi.nlm.nih.gov/33564585 https://doi.org/10.1097/gox.0000000000003355 https://hdl.handle.net/20.500.15037/1299 |
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