Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus)
Defining the pharmacokinetic parameters and depletion intervals for antimicrobials used in fish will help in the development of important guidelines for future regulations by Brazilian agencies on the use of these substances in fish farming. This paper presents a depletion study for enrofloxacin (EN...
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2013
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| author | Jonas Augusto Rizzato Paschoal Silvia Pilco-Quesada Lígia Uribe Gonçalves José Eurico Possebon Cyrino Félix Guillermo Reyes Reyes |
| author_browse | Félix Guillermo Reyes Reyes Jonas Augusto Rizzato Paschoal José Eurico Possebon Cyrino Lígia Uribe Gonçalves Silvia Pilco-Quesada |
| author_facet | Jonas Augusto Rizzato Paschoal Silvia Pilco-Quesada Lígia Uribe Gonçalves José Eurico Possebon Cyrino Félix Guillermo Reyes Reyes |
| author_sort | Jonas Augusto Rizzato Paschoal |
| collection | Producción científica |
| description | Defining the pharmacokinetic parameters and depletion intervals for antimicrobials used in fish will help in the development of important guidelines for future regulations by Brazilian agencies on the use of these substances in fish farming. This paper presents a depletion study for enrofloxacin (ENR) and its main metabolite, ciprofloxacin (CIP), in pacu (Piaractus mesopotamicus) fillets. The depletion study was carried out under monitored environmental conditions, with the temperature controlled at 27 °C to mimic the fish farming conditions in Brazil. ENR was administered orally via medicated feed for 10 consecutive days at daily dosages of 10 mg/kg body weight (b.w.). The fish were slaughtered at 6, 12, and 24 h and 2, 3, 5, 8, 12, 17, and 24 days after the medication period. Considering a maximum residue limit of 100 μg/kg for the sum of the ENR and CIP residues in the fillet, the results obtained in the depletion study allowed the estimation of a half-life for ENR of 2.75 days and a withdrawal period of 23 days. The results obtained in this study are important for the farming of pacu in tropical regions. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1211 |
| institution | UPeU |
| language | English |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/12112026-10-30T16:15:22ZDepletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus)Jonas Augusto Rizzato PaschoalSilvia Pilco-QuesadaLígia Uribe GonçalvesJosé Eurico Possebon CyrinoFélix Guillermo Reyes ReyesPacuPiaractus mesopotamicusEnrofloxacinMaximum Residue LimitResidue (chemistry)Withdrawal timeBody weightAnimal scienceCiprofloxacinChemistryVeterinary medicineBiologyToxicologyFisheryMedicinePesticideAntibioticsPesticide residueMicrobiologyAgronomyBiochemistryColorectal cancerEndocrinologyColonoscopyGeneticsCancerPacuPiaractus mesopotamicusEnrofloxacinMaximum Residue LimitResidue (chemistry)Withdrawal timeBody weightAnimal scienceCiprofloxacinChemistryVeterinary medicineBiologyToxicologyFisheryMedicinePesticideAntibioticsPesticide residueMicrobiologyAgronomyBiochemistryEnrofloxacinEnrofloxacinEnrofloxacinAnimalsAnimalsAnimalsAnti-Bacterial Agents metabolismAnti-Bacterial Agents metabolismAnti-Bacterial Agents metabolismAnti-Bacterial Agents pharmacokineticsAnti-Bacterial Agents pharmacokineticsAnti-Bacterial Agents pharmacokineticsAnti-Bacterial Agents chemistryAnti-Bacterial Agents chemistryAnti-Bacterial Agents chemistryCiprofloxacin metabolismCiprofloxacin metabolismCiprofloxacin metabolismCiprofloxacin pharmacokineticsCiprofloxacin pharmacokineticsCiprofloxacin pharmacokineticsCiprofloxacin chemistryCiprofloxacin chemistryCiprofloxacin chemistryDrug ResiduesDrug ResiduesDrug ResiduesHalf-LifeHalf-LifeHalf-LifeMuscle, Skeletal chemistryMuscle, Skeletal chemistryMuscle, Skeletal chemistryFluoroquinolones metabolismFluoroquinolones metabolismFluoroquinolones metabolismFluoroquinolones pharmacokineticsFluoroquinolones pharmacokineticsFluoroquinolones pharmacokineticsFluoroquinolones chemistryFluoroquinolones chemistryFluoroquinolones chemistryCharaciformes metabolismCharaciformes metabolismCharaciformes metabolismHealth Sciences Medicine Pharmacology Antibiotics Pharmacokinetics and EfficacyPhysical Sciences Environmental Science Pollution Pharmaceutical and Antibiotic Environmental ImpactsLife Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in BacteriaDefining the pharmacokinetic parameters and depletion intervals for antimicrobials used in fish will help in the development of important guidelines for future regulations by Brazilian agencies on the use of these substances in fish farming. This paper presents a depletion study for enrofloxacin (ENR) and its main metabolite, ciprofloxacin (CIP), in pacu (Piaractus mesopotamicus) fillets. The depletion study was carried out under monitored environmental conditions, with the temperature controlled at 27 °C to mimic the fish farming conditions in Brazil. ENR was administered orally via medicated feed for 10 consecutive days at daily dosages of 10 mg/kg body weight (b.w.). The fish were slaughtered at 6, 12, and 24 h and 2, 3, 5, 8, 12, 17, and 24 days after the medication period. Considering a maximum residue limit of 100 μg/kg for the sum of the ENR and CIP residues in the fillet, the results obtained in the depletion study allowed the estimation of a half-life for ENR of 2.75 days and a withdrawal period of 23 days. The results obtained in this study are important for the farming of pacu in tropical regions.Articlehttps://pubmed.ncbi.nlm.nih.gov/23464606https://repositorio.inpa.gov.br/handle/1/2245810.1111/jvp.12043https://hdl.handle.net/20.500.15037/1211W2059401883enJournal of Veterinary Pharmacology and Therapeutics0140-77831365-28852013-03-072026-06-13T09:50:09Z2026-06-13T09:50:09Z |
| spellingShingle | Pacu Piaractus mesopotamicus Enrofloxacin Maximum Residue Limit Residue (chemistry) Withdrawal time Body weight Animal science Ciprofloxacin Chemistry Veterinary medicine Biology Toxicology Fishery Medicine Pesticide Antibiotics Pesticide residue Microbiology Agronomy Biochemistry Colorectal cancer Endocrinology Colonoscopy Genetics Cancer Pacu Piaractus mesopotamicus Enrofloxacin Maximum Residue Limit Residue (chemistry) Withdrawal time Body weight Animal science Ciprofloxacin Chemistry Veterinary medicine Biology Toxicology Fishery Medicine Pesticide Antibiotics Pesticide residue Microbiology Agronomy Biochemistry Enrofloxacin Enrofloxacin Enrofloxacin Animals Animals Animals Anti-Bacterial Agents metabolism Anti-Bacterial Agents metabolism Anti-Bacterial Agents metabolism Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents chemistry Anti-Bacterial Agents chemistry Anti-Bacterial Agents chemistry Ciprofloxacin metabolism Ciprofloxacin metabolism Ciprofloxacin metabolism Ciprofloxacin pharmacokinetics Ciprofloxacin pharmacokinetics Ciprofloxacin pharmacokinetics Ciprofloxacin chemistry Ciprofloxacin chemistry Ciprofloxacin chemistry Drug Residues Drug Residues Drug Residues Half-Life Half-Life Half-Life Muscle, Skeletal chemistry Muscle, Skeletal chemistry Muscle, Skeletal chemistry Fluoroquinolones metabolism Fluoroquinolones metabolism Fluoroquinolones metabolism Fluoroquinolones pharmacokinetics Fluoroquinolones pharmacokinetics Fluoroquinolones pharmacokinetics Fluoroquinolones chemistry Fluoroquinolones chemistry Fluoroquinolones chemistry Characiformes metabolism Characiformes metabolism Characiformes metabolism Health Sciences Medicine Pharmacology Antibiotics Pharmacokinetics and Efficacy Physical Sciences Environmental Science Pollution Pharmaceutical and Antibiotic Environmental Impacts Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in Bacteria Jonas Augusto Rizzato Paschoal Silvia Pilco-Quesada Lígia Uribe Gonçalves José Eurico Possebon Cyrino Félix Guillermo Reyes Reyes Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus) |
| title | Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus) |
| title_full | Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus) |
| title_fullStr | Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus) |
| title_full_unstemmed | Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus) |
| title_short | Depletion study and estimation of the withdrawal period for enrofloxacin in pacu (P iaractus mesopotamicus) |
| title_sort | depletion study and estimation of the withdrawal period for enrofloxacin in pacu p iaractus mesopotamicus |
| topic | Pacu Piaractus mesopotamicus Enrofloxacin Maximum Residue Limit Residue (chemistry) Withdrawal time Body weight Animal science Ciprofloxacin Chemistry Veterinary medicine Biology Toxicology Fishery Medicine Pesticide Antibiotics Pesticide residue Microbiology Agronomy Biochemistry Colorectal cancer Endocrinology Colonoscopy Genetics Cancer Pacu Piaractus mesopotamicus Enrofloxacin Maximum Residue Limit Residue (chemistry) Withdrawal time Body weight Animal science Ciprofloxacin Chemistry Veterinary medicine Biology Toxicology Fishery Medicine Pesticide Antibiotics Pesticide residue Microbiology Agronomy Biochemistry Enrofloxacin Enrofloxacin Enrofloxacin Animals Animals Animals Anti-Bacterial Agents metabolism Anti-Bacterial Agents metabolism Anti-Bacterial Agents metabolism Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents chemistry Anti-Bacterial Agents chemistry Anti-Bacterial Agents chemistry Ciprofloxacin metabolism Ciprofloxacin metabolism Ciprofloxacin metabolism Ciprofloxacin pharmacokinetics Ciprofloxacin pharmacokinetics Ciprofloxacin pharmacokinetics Ciprofloxacin chemistry Ciprofloxacin chemistry Ciprofloxacin chemistry Drug Residues Drug Residues Drug Residues Half-Life Half-Life Half-Life Muscle, Skeletal chemistry Muscle, Skeletal chemistry Muscle, Skeletal chemistry Fluoroquinolones metabolism Fluoroquinolones metabolism Fluoroquinolones metabolism Fluoroquinolones pharmacokinetics Fluoroquinolones pharmacokinetics Fluoroquinolones pharmacokinetics Fluoroquinolones chemistry Fluoroquinolones chemistry Fluoroquinolones chemistry Characiformes metabolism Characiformes metabolism Characiformes metabolism Health Sciences Medicine Pharmacology Antibiotics Pharmacokinetics and Efficacy Physical Sciences Environmental Science Pollution Pharmaceutical and Antibiotic Environmental Impacts Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in Bacteria |
| topic_facet | Pacu Piaractus mesopotamicus Enrofloxacin Maximum Residue Limit Residue (chemistry) Withdrawal time Body weight Animal science Ciprofloxacin Chemistry Veterinary medicine Biology Toxicology Fishery Medicine Pesticide Antibiotics Pesticide residue Microbiology Agronomy Biochemistry Colorectal cancer Endocrinology Colonoscopy Genetics Cancer Pacu Piaractus mesopotamicus Enrofloxacin Maximum Residue Limit Residue (chemistry) Withdrawal time Body weight Animal science Ciprofloxacin Chemistry Veterinary medicine Biology Toxicology Fishery Medicine Pesticide Antibiotics Pesticide residue Microbiology Agronomy Biochemistry Enrofloxacin Enrofloxacin Enrofloxacin Animals Animals Animals Anti-Bacterial Agents metabolism Anti-Bacterial Agents metabolism Anti-Bacterial Agents metabolism Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents pharmacokinetics Anti-Bacterial Agents chemistry Anti-Bacterial Agents chemistry Anti-Bacterial Agents chemistry Ciprofloxacin metabolism Ciprofloxacin metabolism Ciprofloxacin metabolism Ciprofloxacin pharmacokinetics Ciprofloxacin pharmacokinetics Ciprofloxacin pharmacokinetics Ciprofloxacin chemistry Ciprofloxacin chemistry Ciprofloxacin chemistry Drug Residues Drug Residues Drug Residues Half-Life Half-Life Half-Life Muscle, Skeletal chemistry Muscle, Skeletal chemistry Muscle, Skeletal chemistry Fluoroquinolones metabolism Fluoroquinolones metabolism Fluoroquinolones metabolism Fluoroquinolones pharmacokinetics Fluoroquinolones pharmacokinetics Fluoroquinolones pharmacokinetics Fluoroquinolones chemistry Fluoroquinolones chemistry Fluoroquinolones chemistry Characiformes metabolism Characiformes metabolism Characiformes metabolism Health Sciences Medicine Pharmacology Antibiotics Pharmacokinetics and Efficacy Physical Sciences Environmental Science Pollution Pharmaceutical and Antibiotic Environmental Impacts Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Medicine Antibiotic Resistance in Bacteria |
| url | https://pubmed.ncbi.nlm.nih.gov/23464606 https://repositorio.inpa.gov.br/handle/1/22458 https://hdl.handle.net/20.500.15037/1211 |
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