Potential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro study
The study's objective is to determine the inhibitory effect of Atorvastatin calcium on bacte-rial growth in vitro, which would demonstrate a pleiotropic effect of this compound. It was performed using the paper diffusion technique, in which 3 ATCC strains were tested: Pseudomonas aeruginosa, Es...
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| Lenguaje: | español |
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2024
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| author | Yareta Yareta, José Luis |
| author_browse | Yareta Yareta, José Luis |
| author_facet | Yareta Yareta, José Luis |
| author_sort | Yareta Yareta, José Luis |
| collection | Producción científica |
| description | The study's objective is to determine the inhibitory effect of Atorvastatin calcium on bacte-rial growth in vitro, which would demonstrate a pleiotropic effect of this compound. It was performed using the paper diffusion technique, in which 3 ATCC strains were tested: Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus, with 6 replicates for each one. The test system consisted of Atorvastatin calcium concentrations of 250 μg and 500 μg; positive control Aztreonam 30 μg, Trimethoprim/sulfamethoxazole 25 μg and Cefoxitin 30 μg and negative control ethanol were also used. Data were processed in Stata v17. The results showed inhibition halos of 6 mm at 250 μg and 500 μg concentrations of Atorvastatin for all experimental samples. In vitro Atorvastatin, at concentrations of 250 μg and 500 μg, showed no inhibitory effect against the bacterial strains studied. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1197 |
| institution | UPeU |
| language | Spanish |
| publishDate | 2024 |
| publishDateRange | 2024 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/11972026-11-02T12:57:04ZPotential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro studyYareta Yareta, José LuisAntibacterialsAtorvastatinEscherichia coliStaphylococcus aureusPseudomonas ae-ruginosapleiotropicThe study's objective is to determine the inhibitory effect of Atorvastatin calcium on bacte-rial growth in vitro, which would demonstrate a pleiotropic effect of this compound. It was performed using the paper diffusion technique, in which 3 ATCC strains were tested: Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus, with 6 replicates for each one. The test system consisted of Atorvastatin calcium concentrations of 250 μg and 500 μg; positive control Aztreonam 30 μg, Trimethoprim/sulfamethoxazole 25 μg and Cefoxitin 30 μg and negative control ethanol were also used. Data were processed in Stata v17. The results showed inhibition halos of 6 mm at 250 μg and 500 μg concentrations of Atorvastatin for all experimental samples. In vitro Atorvastatin, at concentrations of 250 μg and 500 μg, showed no inhibitory effect against the bacterial strains studied.Articlehttps://bionaturajournal.com/files/3-BJN-2024.01.02.5.pdfhttps://doi.org/10.70099/bj/2024.01.02.510.70099/bj/2024.01.02.5https://hdl.handle.net/20.500.15037/1197W4402341067esBionatura journal :3020-78862024-06-152026-06-13T09:49:47Z2026-06-13T09:49:47Z |
| spellingShingle | Antibacterials Atorvastatin Escherichia coli Staphylococcus aureus Pseudomonas ae-ruginosa pleiotropic Yareta Yareta, José Luis Potential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro study |
| title | Potential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro study |
| title_full | Potential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro study |
| title_fullStr | Potential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro study |
| title_full_unstemmed | Potential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro study |
| title_short | Potential pleiotropic effect of Atorvastatin: bacterial growth inhibitor, in vitro study |
| title_sort | potential pleiotropic effect of atorvastatin bacterial growth inhibitor in vitro study |
| topic | Antibacterials Atorvastatin Escherichia coli Staphylococcus aureus Pseudomonas ae-ruginosa pleiotropic |
| topic_facet | Antibacterials Atorvastatin Escherichia coli Staphylococcus aureus Pseudomonas ae-ruginosa pleiotropic |
| url | https://bionaturajournal.com/files/3-BJN-2024.01.02.5.pdf https://doi.org/10.70099/bj/2024.01.02.5 https://hdl.handle.net/20.500.15037/1197 |
| work_keys_str_mv | AT yaretayaretajoseluis potentialpleiotropiceffectofatorvastatinbacterialgrowthinhibitorinvitrostudy |