Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells
Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses,...
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2021
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| author | Samanta Melgar‐Rodríguez Emilio A. Cafferata Nicolás Díaz M.A. Peña Luis González Carolina Rojas Alfredo Sierra‐Cristancho Angélica M. Cárdenas Jaime Díaz‐Zúñiga Rolando Vernal |
| author_browse | Alfredo Sierra‐Cristancho Angélica M. Cárdenas Carolina Rojas Emilio A. Cafferata Jaime Díaz‐Zúñiga Luis González M.A. Peña Nicolás Díaz Rolando Vernal Samanta Melgar‐Rodríguez |
| author_facet | Samanta Melgar‐Rodríguez Emilio A. Cafferata Nicolás Díaz M.A. Peña Luis González Carolina Rojas Alfredo Sierra‐Cristancho Angélica M. Cárdenas Jaime Díaz‐Zúñiga Rolando Vernal |
| author_sort | Samanta Melgar‐Rodríguez |
| collection | Producción científica |
| description | Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses, depending on their production of proinflammatory or anti-inflammatory cytokines, respectively. Effector NKT cells are subdivided into three subsets, termed NKT1, NKT2, and NKT17, based on the cytokines they produce and their similarity to the cytokine profile produced by Th1, Th2, and Th17 lymphocytes, respectively. Recently, a new subgroup of NKT cells termed NKT10 has been described, which cooperates and interacts with other immune cells to promote immunoregulatory responses. Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells. |
| format | Other |
| id | oai:cris.upeu.edu.pe:20.500.15037/1192 |
| institution | UPeU |
| language | English |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/11922026-10-30T16:15:20ZNatural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 CellsSamanta Melgar‐RodríguezEmilio A. CafferataNicolás DíazM.A. PeñaLuis GonzálezCarolina RojasAlfredo Sierra‐CristanchoAngélica M. CárdenasJaime Díaz‐ZúñigaRolando VernalNatural killer T cellImmunologyImmune systemBiologyProinflammatory cytokineCD1DCytokineInflammationT cellNatural killer T cellImmunologyImmune systemBiologyProinflammatory cytokineCD1DCytokineInflammationT cellAnimalsAnimalsAnimalsGlycolipids chemistryGlycolipids chemistryGlycolipids chemistryHumansHumansHumansLymphocyte ActivationLymphocyte ActivationLymphocyte ActivationPeriodontitis etiologyPeriodontitis etiologyPeriodontitis etiologyPeriodontitis immunologyPeriodontitis immunologyPeriodontitis immunologyCytokines physiologyCytokines physiologyCytokines physiologyAntigens, CD1d chemistryAntigens, CD1d chemistryAntigens, CD1d chemistryNatural Killer T-Cells cytologyNatural Killer T-Cells cytologyNatural Killer T-Cells cytologyNatural Killer T-Cells physiologyNatural Killer T-Cells physiologyNatural Killer T-Cells physiologyLife Sciences Immunology and Microbiology Immunology Immune Cell Function and InteractionLife Sciences Immunology and Microbiology Immunology IL-33, ST2, and ILC PathwaysLife Sciences Immunology and Microbiology Immunology T-cell and B-cell ImmunologyNatural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses, depending on their production of proinflammatory or anti-inflammatory cytokines, respectively. Effector NKT cells are subdivided into three subsets, termed NKT1, NKT2, and NKT17, based on the cytokines they produce and their similarity to the cytokine profile produced by Th1, Th2, and Th17 lymphocytes, respectively. Recently, a new subgroup of NKT cells termed NKT10 has been described, which cooperates and interacts with other immune cells to promote immunoregulatory responses. Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells.Otherhttps://pubmed.ncbi.nlm.nih.gov/34594157https://downloads.hindawi.com/journals/mi/2021/5573937.pdfhttps://doi.org/10.1155/2021/557393710.1155/2021/5573937https://hdl.handle.net/20.500.15037/1192W3201077096enMediators of Inflammation0962-93511466-18612021-01-012026-06-13T09:49:33Z2026-06-13T09:49:33Z |
| spellingShingle | Natural killer T cell Immunology Immune system Biology Proinflammatory cytokine CD1D Cytokine Inflammation T cell Natural killer T cell Immunology Immune system Biology Proinflammatory cytokine CD1D Cytokine Inflammation T cell Animals Animals Animals Glycolipids chemistry Glycolipids chemistry Glycolipids chemistry Humans Humans Humans Lymphocyte Activation Lymphocyte Activation Lymphocyte Activation Periodontitis etiology Periodontitis etiology Periodontitis etiology Periodontitis immunology Periodontitis immunology Periodontitis immunology Cytokines physiology Cytokines physiology Cytokines physiology Antigens, CD1d chemistry Antigens, CD1d chemistry Antigens, CD1d chemistry Natural Killer T-Cells cytology Natural Killer T-Cells cytology Natural Killer T-Cells cytology Natural Killer T-Cells physiology Natural Killer T-Cells physiology Natural Killer T-Cells physiology Life Sciences Immunology and Microbiology Immunology Immune Cell Function and Interaction Life Sciences Immunology and Microbiology Immunology IL-33, ST2, and ILC Pathways Life Sciences Immunology and Microbiology Immunology T-cell and B-cell Immunology Samanta Melgar‐Rodríguez Emilio A. Cafferata Nicolás Díaz M.A. Peña Luis González Carolina Rojas Alfredo Sierra‐Cristancho Angélica M. Cárdenas Jaime Díaz‐Zúñiga Rolando Vernal Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_full | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_fullStr | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_full_unstemmed | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_short | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_sort | natural killer t nkt cells and periodontitis potential regulatory role of nkt10 cells |
| topic | Natural killer T cell Immunology Immune system Biology Proinflammatory cytokine CD1D Cytokine Inflammation T cell Natural killer T cell Immunology Immune system Biology Proinflammatory cytokine CD1D Cytokine Inflammation T cell Animals Animals Animals Glycolipids chemistry Glycolipids chemistry Glycolipids chemistry Humans Humans Humans Lymphocyte Activation Lymphocyte Activation Lymphocyte Activation Periodontitis etiology Periodontitis etiology Periodontitis etiology Periodontitis immunology Periodontitis immunology Periodontitis immunology Cytokines physiology Cytokines physiology Cytokines physiology Antigens, CD1d chemistry Antigens, CD1d chemistry Antigens, CD1d chemistry Natural Killer T-Cells cytology Natural Killer T-Cells cytology Natural Killer T-Cells cytology Natural Killer T-Cells physiology Natural Killer T-Cells physiology Natural Killer T-Cells physiology Life Sciences Immunology and Microbiology Immunology Immune Cell Function and Interaction Life Sciences Immunology and Microbiology Immunology IL-33, ST2, and ILC Pathways Life Sciences Immunology and Microbiology Immunology T-cell and B-cell Immunology |
| topic_facet | Natural killer T cell Immunology Immune system Biology Proinflammatory cytokine CD1D Cytokine Inflammation T cell Natural killer T cell Immunology Immune system Biology Proinflammatory cytokine CD1D Cytokine Inflammation T cell Animals Animals Animals Glycolipids chemistry Glycolipids chemistry Glycolipids chemistry Humans Humans Humans Lymphocyte Activation Lymphocyte Activation Lymphocyte Activation Periodontitis etiology Periodontitis etiology Periodontitis etiology Periodontitis immunology Periodontitis immunology Periodontitis immunology Cytokines physiology Cytokines physiology Cytokines physiology Antigens, CD1d chemistry Antigens, CD1d chemistry Antigens, CD1d chemistry Natural Killer T-Cells cytology Natural Killer T-Cells cytology Natural Killer T-Cells cytology Natural Killer T-Cells physiology Natural Killer T-Cells physiology Natural Killer T-Cells physiology Life Sciences Immunology and Microbiology Immunology Immune Cell Function and Interaction Life Sciences Immunology and Microbiology Immunology IL-33, ST2, and ILC Pathways Life Sciences Immunology and Microbiology Immunology T-cell and B-cell Immunology |
| url | https://pubmed.ncbi.nlm.nih.gov/34594157 https://downloads.hindawi.com/journals/mi/2021/5573937.pdf https://doi.org/10.1155/2021/5573937 https://hdl.handle.net/20.500.15037/1192 |
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