Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study
Introduction: There is limited research on long-term neurologic symptoms following SARS-CoV-2 infection in Peru. This study aimed to describe the longitudinal experience of survivors of mild to moderate COVID-19 in Lima, Peru. Methods: This prospective, longitudinal observational study included neur...
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2025
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| author | Hanalise V. Huff Carla Villanueva-Colina Monica M. Diaz Sofia Tovar Andrea Davila Luna Tianxia Wu Davidson H. Hamer Igor J. Koralnik Tom Solomon Miguela A. Caniza Patricia García |
| author_browse | Andrea Davila Luna Carla Villanueva-Colina Davidson H. Hamer Hanalise V. Huff Igor J. Koralnik Miguela A. Caniza Monica M. Diaz Patricia García Sofia Tovar Tianxia Wu Tom Solomon |
| author_facet | Hanalise V. Huff Carla Villanueva-Colina Monica M. Diaz Sofia Tovar Andrea Davila Luna Tianxia Wu Davidson H. Hamer Igor J. Koralnik Tom Solomon Miguela A. Caniza Patricia García |
| author_sort | Hanalise V. Huff |
| collection | Producción científica |
| description | Introduction: There is limited research on long-term neurologic symptoms following SARS-CoV-2 infection in Peru. This study aimed to describe the longitudinal experience of survivors of mild to moderate COVID-19 in Lima, Peru. Methods: This prospective, longitudinal observational study included neurologic follow-up data between 3- and 12-months following SARS-CoV-2 infection. Recruitment to a parent study: "Natural History of SARS-CoV-2 in Comparison to Influenza Virus: A Multi-site Study Focused on the Southern Hemisphere and Equatorial Regions" (COFLU Peru), occurred between February 2021 and February 2022 in a Callao, Peru public hospital emergency department. In-person visits for this sub-study, "Neuro COFLU," included neurologic history and symptom questionnaire. Results: Fifty-four patients were seen for at least one visit, two of whom required hospitalization for COVID-19. Forty-one (76%) reported at least one pre-existing neurologic diagnosis (59% headaches; 24% migraines). At follow-up visits, patients reported at least one new neurologic symptom since COVID-19: 24/29 (83%) at 90 days, 31/42 (74%) at 180 days, 41/46 (89%) at 270 days, and 20/21 (95%) at 365 days. The median number of new symptoms was 3 at 90 days, 3 at 180, 4 at 270 and 3 at 365 days. Days 90-180 frequent symptoms included: muscular pain, neck stiffness, headache, loss of appetite, numbness, insomnia, and weakness (24-31%). Days 181-365 frequent symptoms included: fatigue, weakness, memory problems, irritability, changes in hearing, muscular pain, joint pain, and insomnia (28-33%). Pre-existing anxiety was associated with post-COVID-19 hearing changes, muscular pain, numbness and weakness and pre-existing depression with neck stiffness and numbness. No significant association was found with age, sex, vaccination status, or pre-existing headaches. Full recovery was reported for 6/29 (21%) at day 90, 13/42 (31%) at day 180, 17/46 (37%) at day 270, and 9/20 (45%) at day 365. By day 365, patients reported median recovery of 85-90%. Discussion: Persistent neurological symptoms are common in COVID-19 survivors in Lima. Many new neurologic symptoms persisted and increased in prevalence over 3-12 months. Limitations include lack of control group and small sample size. Longitudinal studies of outcomes are needed to predict and mitigate the long-term physical, social and economic effects of SARS-CoV-2 infection. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1167 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/11672026-10-30T16:15:18ZNeurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational studyHanalise V. HuffCarla Villanueva-ColinaMonica M. DiazSofia TovarAndrea Davila LunaTianxia WuDavidson H. HamerIgor J. KoralnikTom SolomonMiguela A. CanizaPatricia GarcíaObservational studyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMedicineProspective cohort studyVirologyInternal medicineOutbreakDiseaseInfectious disease (medical specialty)Observational studyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMedicineProspective cohort studyVirologyInternal medicineOutbreakDiseaseHealth Sciences Medicine Neurology Long-Term Effects of COVID-19Social Sciences Psychology Clinical Psychology COVID-19 and Mental HealthLife Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and EffectsIntroduction: There is limited research on long-term neurologic symptoms following SARS-CoV-2 infection in Peru. This study aimed to describe the longitudinal experience of survivors of mild to moderate COVID-19 in Lima, Peru. Methods: This prospective, longitudinal observational study included neurologic follow-up data between 3- and 12-months following SARS-CoV-2 infection. Recruitment to a parent study: "Natural History of SARS-CoV-2 in Comparison to Influenza Virus: A Multi-site Study Focused on the Southern Hemisphere and Equatorial Regions" (COFLU Peru), occurred between February 2021 and February 2022 in a Callao, Peru public hospital emergency department. In-person visits for this sub-study, "Neuro COFLU," included neurologic history and symptom questionnaire. Results: Fifty-four patients were seen for at least one visit, two of whom required hospitalization for COVID-19. Forty-one (76%) reported at least one pre-existing neurologic diagnosis (59% headaches; 24% migraines). At follow-up visits, patients reported at least one new neurologic symptom since COVID-19: 24/29 (83%) at 90 days, 31/42 (74%) at 180 days, 41/46 (89%) at 270 days, and 20/21 (95%) at 365 days. The median number of new symptoms was 3 at 90 days, 3 at 180, 4 at 270 and 3 at 365 days. Days 90-180 frequent symptoms included: muscular pain, neck stiffness, headache, loss of appetite, numbness, insomnia, and weakness (24-31%). Days 181-365 frequent symptoms included: fatigue, weakness, memory problems, irritability, changes in hearing, muscular pain, joint pain, and insomnia (28-33%). Pre-existing anxiety was associated with post-COVID-19 hearing changes, muscular pain, numbness and weakness and pre-existing depression with neck stiffness and numbness. No significant association was found with age, sex, vaccination status, or pre-existing headaches. Full recovery was reported for 6/29 (21%) at day 90, 13/42 (31%) at day 180, 17/46 (37%) at day 270, and 9/20 (45%) at day 365. By day 365, patients reported median recovery of 85-90%. Discussion: Persistent neurological symptoms are common in COVID-19 survivors in Lima. Many new neurologic symptoms persisted and increased in prevalence over 3-12 months. Limitations include lack of control group and small sample size. Longitudinal studies of outcomes are needed to predict and mitigate the long-term physical, social and economic effects of SARS-CoV-2 infection.Articlehttps://pubmed.ncbi.nlm.nih.gov/40761637https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1524613/pdfhttps://doi.org/10.3389/fneur.2025.152461310.3389/fneur.2025.1524613https://hdl.handle.net/20.500.15037/1167W4412527170enFrontiers in Neurology1664-22952025-07-212026-06-13T09:48:26Z2026-06-13T09:48:26Z |
| spellingShingle | Observational study Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2019-20 coronavirus outbreak Medicine Prospective cohort study Virology Internal medicine Outbreak Disease Infectious disease (medical specialty) Observational study Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2019-20 coronavirus outbreak Medicine Prospective cohort study Virology Internal medicine Outbreak Disease Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Social Sciences Psychology Clinical Psychology COVID-19 and Mental Health Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and Effects Hanalise V. Huff Carla Villanueva-Colina Monica M. Diaz Sofia Tovar Andrea Davila Luna Tianxia Wu Davidson H. Hamer Igor J. Koralnik Tom Solomon Miguela A. Caniza Patricia García Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study |
| title | Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study |
| title_full | Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study |
| title_fullStr | Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study |
| title_full_unstemmed | Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study |
| title_short | Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study |
| title_sort | neurologic symptoms following covid 19 in lima peru a prospective longitudinal observational study |
| topic | Observational study Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2019-20 coronavirus outbreak Medicine Prospective cohort study Virology Internal medicine Outbreak Disease Infectious disease (medical specialty) Observational study Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2019-20 coronavirus outbreak Medicine Prospective cohort study Virology Internal medicine Outbreak Disease Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Social Sciences Psychology Clinical Psychology COVID-19 and Mental Health Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and Effects |
| topic_facet | Observational study Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2019-20 coronavirus outbreak Medicine Prospective cohort study Virology Internal medicine Outbreak Disease Infectious disease (medical specialty) Observational study Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2019-20 coronavirus outbreak Medicine Prospective cohort study Virology Internal medicine Outbreak Disease Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Social Sciences Psychology Clinical Psychology COVID-19 and Mental Health Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and Effects |
| url | https://pubmed.ncbi.nlm.nih.gov/40761637 https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1524613/pdf https://doi.org/10.3389/fneur.2025.1524613 https://hdl.handle.net/20.500.15037/1167 |
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