Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations
Background The presence of benzene, toluene, ethylbenzene, and xylene isomers (BTEX) in the environment is of increasing concern due to their toxicity and ubiquity.Although the adverse health effects of BTEX exposure have been documented, robust epidemiological evidence from large-scale, multicountr...
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| author | Lu Zhou Xiong Ying Francesco Sera Ana Maria Vicedo-Cabrera Rosana Abrutzky Yuming Guo Shilu Tong Micheline de Sousa Zanotti Stagliorio Coêlho Paulo Hilario Nascimento Saldiva Éric Lavigne Patricia Matus Correa Nicolás Valdés Ortega Samuel Osorio Dominic Royé Jan Kyselý Hans Orru Marek Maasikmets Jouni J. K. Jaakkola Niilo Ryti Mathilde Pascal Veronika Huber Susanne Breitner-Busch Alexandra Schneider Klea Katsouyanni Evangelia Samoli Alireza Entezari Fatemeh Mayvaneh Patrick Goodman Ariana Zeka Raanan Raz Matteo Scortichini Massimo Stafoggia Yasushi Honda Masahiro Hashizume Chris Fook Sheng Ng Barrak Alahmad Magali Hurtado‐Díaz Eunice Elizabeth Félix Arellano Ala Overcenco Jochem O. Klompmaker Shilpa Rao Gabriel Carrasco‐Escobar Xerxes Seposo Paul Lester Chua Susana Pereira Silva Joana Madureira Iulian‐Horia Holobâcă Noah Scovronick Rebecca M. Garland Ho Kim Whanhee Lee Aurelio Tobı́as Carmen Íñiguez Bertil Forsberg Martina S. Ragettli Yue Leon Guo Shih‐Chun Pan Shanshan Li Pierre Masselot Valentina Colistro Michelle L. Bell Antonella Zanobetti Joel Schwartz Trần Ngọc Đăng Do Van Dung Antonio Gasparrini Yaoxian Huang Haidong Kan |
| author_browse | Ala Overcenco Alexandra Schneider Alireza Entezari Ana Maria Vicedo-Cabrera Antonella Zanobetti Antonio Gasparrini Ariana Zeka Aurelio Tobı́as Barrak Alahmad Bertil Forsberg Carmen Íñiguez Chris Fook Sheng Ng Do Van Dung Dominic Royé Eunice Elizabeth Félix Arellano Evangelia Samoli Fatemeh Mayvaneh Francesco Sera Gabriel Carrasco‐Escobar Haidong Kan Hans Orru Ho Kim Iulian‐Horia Holobâcă Jan Kyselý Joana Madureira Jochem O. Klompmaker Joel Schwartz Jouni J. K. Jaakkola Klea Katsouyanni Lu Zhou Magali Hurtado‐Díaz Marek Maasikmets Martina S. Ragettli Masahiro Hashizume Massimo Stafoggia Mathilde Pascal Matteo Scortichini Micheline de Sousa Zanotti Stagliorio Coêlho Michelle L. Bell Nicolás Valdés Ortega Niilo Ryti Noah Scovronick Patricia Matus Correa Patrick Goodman Paul Lester Chua Paulo Hilario Nascimento Saldiva Pierre Masselot Raanan Raz Rebecca M. Garland Rosana Abrutzky Samuel Osorio Shanshan Li Shih‐Chun Pan Shilpa Rao Shilu Tong Susana Pereira Silva Susanne Breitner-Busch Trần Ngọc Đăng Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Xiong Ying Yaoxian Huang Yasushi Honda Yue Leon Guo Yuming Guo Éric Lavigne |
| author_facet | Lu Zhou Xiong Ying Francesco Sera Ana Maria Vicedo-Cabrera Rosana Abrutzky Yuming Guo Shilu Tong Micheline de Sousa Zanotti Stagliorio Coêlho Paulo Hilario Nascimento Saldiva Éric Lavigne Patricia Matus Correa Nicolás Valdés Ortega Samuel Osorio Dominic Royé Jan Kyselý Hans Orru Marek Maasikmets Jouni J. K. Jaakkola Niilo Ryti Mathilde Pascal Veronika Huber Susanne Breitner-Busch Alexandra Schneider Klea Katsouyanni Evangelia Samoli Alireza Entezari Fatemeh Mayvaneh Patrick Goodman Ariana Zeka Raanan Raz Matteo Scortichini Massimo Stafoggia Yasushi Honda Masahiro Hashizume Chris Fook Sheng Ng Barrak Alahmad Magali Hurtado‐Díaz Eunice Elizabeth Félix Arellano Ala Overcenco Jochem O. Klompmaker Shilpa Rao Gabriel Carrasco‐Escobar Xerxes Seposo Paul Lester Chua Susana Pereira Silva Joana Madureira Iulian‐Horia Holobâcă Noah Scovronick Rebecca M. Garland Ho Kim Whanhee Lee Aurelio Tobı́as Carmen Íñiguez Bertil Forsberg Martina S. Ragettli Yue Leon Guo Shih‐Chun Pan Shanshan Li Pierre Masselot Valentina Colistro Michelle L. Bell Antonella Zanobetti Joel Schwartz Trần Ngọc Đăng Do Van Dung Antonio Gasparrini Yaoxian Huang Haidong Kan |
| author_sort | Lu Zhou |
| collection | Producción científica |
| description | Background The presence of benzene, toluene, ethylbenzene, and xylene isomers (BTEX) in the environment is of increasing concern due to their toxicity and ubiquity.Although the adverse health effects of BTEX exposure have been documented, robust epidemiological evidence from large-scale, multicountry studies using advanced exposure assessment methodologies remains scarce.We aimed to assess the association of short-term ambient exposure to individual BTEX components and their mixture with daily total, cardiovascular, and respiratory mortality on a global scale. Methods Daily data on mortality, meteorological factors, and air pollution were collected from 757 locations across 46 countries or regions. Data on individual chemicals (ie, benzene, toluene, xylenes [summation of ethylbenzene, m-xylene, p-xylene, and o-xylene]) and the aggregate mixture (ie, BTEX) were estimated using a chemistry-climate model.We examined the short-term associations of each individual chemical as well as the BTEX mixture with daily total, cardiovascular, and respiratory mortality in a multicountry framework.Using a two-stage time-series design, we first applied generalised additive models with a quasi-Poisson distribution to obtain location-specific associations, which were subsequently pooled using random-effects meta-analysis.Two-pollutant models were used to assess the independent effects of BTEX after adjusting for co-pollutants (PM 25 , PM 10 , nitrogen dioxide, sulphur dioxide, ozone, and carbon monoxide).Additionally, we assessed the overall exposure-response curves with spline terms.Findings An IQR increment of BTEX concentration on lag 0-2 days (3-day moving average of the present day and the previous 2 days) was associated with increases of 057% (95% CI 049-065), 042% (030-054), and 068% (050-086) in total, cardiovascular, and respiratory mortality, respectively.The corresponding effect estimates for an IQR increment in individual chemicals (benzene, toluene, and xylenes) were 038-061%, 044-070%, and 041-065%, respectively.The associations remained significant after adjusting for co-pollutants, with a general decline in magnitude, except for a slight increase after adjustment for ozone.The shape of the exposureresponse curves for all pollutants and causes of death was almost linear, with steeper slopes at low concentrations and no discernible thresholds.Interpretation This global study provides novel evidence linking short-term exposure to ambient BTEX, both individually and as a mixture, with increased daily total, cardiovascular, and respiratory mortality.Our findings underscore the need for comprehensive air pollution mitigation policies, including stringent controls on BTEX emissions, to protect public health. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1165 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/11652026-10-30T16:15:17ZAssociations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locationsLu ZhouXiong YingFrancesco SeraAna Maria Vicedo-CabreraRosana AbrutzkyYuming GuoShilu TongMicheline de Sousa Zanotti Stagliorio CoêlhoPaulo Hilario Nascimento SaldivaÉric LavignePatricia Matus CorreaNicolás Valdés OrtegaSamuel OsorioDominic RoyéJan KyselýHans OrruMarek MaasikmetsJouni J. K. JaakkolaNiilo RytiMathilde PascalVeronika HuberSusanne Breitner-BuschAlexandra SchneiderKlea KatsouyanniEvangelia SamoliAlireza EntezariFatemeh MayvanehPatrick GoodmanAriana ZekaRaanan RazMatteo ScortichiniMassimo StafoggiaYasushi HondaMasahiro HashizumeChris Fook Sheng NgBarrak AlahmadMagali Hurtado‐DíazEunice Elizabeth Félix ArellanoAla OvercencoJochem O. KlompmakerShilpa RaoGabriel Carrasco‐EscobarXerxes SeposoPaul Lester ChuaSusana Pereira SilvaJoana MadureiraIulian‐Horia HolobâcăNoah ScovronickRebecca M. GarlandHo KimWhanhee LeeAurelio Tobı́asCarmen ÍñiguezBertil ForsbergMartina S. RagettliYue Leon GuoShih‐Chun PanShanshan LiPierre MasselotValentina ColistroMichelle L. BellAntonella ZanobettiJoel SchwartzTrần Ngọc ĐăngDo Van DungAntonio GasparriniYaoxian HuangHaidong KanEnvironmental scienceGeneral partnershipEnvironmental healthJoint (building)Environmental planningEnvironmental protectionNatural (archaeology)Foundation (evidence)Exposure assessmentEnvironmental engineeringHuman healthXyleneHeavy metalsGeneral partnershipJoint (building)Natural (archaeology)Foundation (evidence)Exposure assessmentAir Pollutants adverse effectsAir Pollutants adverse effectsAir Pollutants analysisAir Pollutants analysisAir Pollutants toxicityAir Pollutants toxicityAir Pollution adverse effectsAir Pollution adverse effectsBenzene adverse effectsBenzene adverse effectsBenzene analysisBenzene analysisBenzene toxicityBenzene toxicityBenzene Derivatives adverse effectsBenzene Derivatives adverse effectsBenzene Derivatives analysisBenzene Derivatives analysisBenzene Derivatives toxicityBenzene Derivatives toxicityCardiovascular Diseases mortalityCardiovascular Diseases mortalityEnvironmental Exposure adverse effectsEnvironmental Exposure adverse effectsHumansHumansMortalityMortalityRespiratory Tract Diseases chemically inducedRespiratory Tract Diseases chemically inducedRespiratory Tract Diseases mortalityRespiratory Tract Diseases mortalityToluene adverse effectsToluene adverse effectsToluene analysisToluene analysisToluene toxicityToluene toxicityXylenes adverse effectsXylenes adverse effectsXylenes analysisXylenes analysisXylenes toxicityXylenes toxicityPhysical Sciences Environmental Science Health, Toxicology and Mutagenesis Indoor Air Quality and Microbial ExposureLife Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Carcinogens and Genotoxicity AssessmentPhysical Sciences Environmental Science Health, Toxicology and Mutagenesis Air Quality and Health ImpactsBackground The presence of benzene, toluene, ethylbenzene, and xylene isomers (BTEX) in the environment is of increasing concern due to their toxicity and ubiquity.Although the adverse health effects of BTEX exposure have been documented, robust epidemiological evidence from large-scale, multicountry studies using advanced exposure assessment methodologies remains scarce.We aimed to assess the association of short-term ambient exposure to individual BTEX components and their mixture with daily total, cardiovascular, and respiratory mortality on a global scale. Methods Daily data on mortality, meteorological factors, and air pollution were collected from 757 locations across 46 countries or regions. Data on individual chemicals (ie, benzene, toluene, xylenes [summation of ethylbenzene, m-xylene, p-xylene, and o-xylene]) and the aggregate mixture (ie, BTEX) were estimated using a chemistry-climate model.We examined the short-term associations of each individual chemical as well as the BTEX mixture with daily total, cardiovascular, and respiratory mortality in a multicountry framework.Using a two-stage time-series design, we first applied generalised additive models with a quasi-Poisson distribution to obtain location-specific associations, which were subsequently pooled using random-effects meta-analysis.Two-pollutant models were used to assess the independent effects of BTEX after adjusting for co-pollutants (PM 25 , PM 10 , nitrogen dioxide, sulphur dioxide, ozone, and carbon monoxide).Additionally, we assessed the overall exposure-response curves with spline terms.Findings An IQR increment of BTEX concentration on lag 0-2 days (3-day moving average of the present day and the previous 2 days) was associated with increases of 057% (95% CI 049-065), 042% (030-054), and 068% (050-086) in total, cardiovascular, and respiratory mortality, respectively.The corresponding effect estimates for an IQR increment in individual chemicals (benzene, toluene, and xylenes) were 038-061%, 044-070%, and 041-065%, respectively.The associations remained significant after adjusting for co-pollutants, with a general decline in magnitude, except for a slight increase after adjustment for ozone.The shape of the exposureresponse curves for all pollutants and causes of death was almost linear, with steeper slopes at low concentrations and no discernible thresholds.Interpretation This global study provides novel evidence linking short-term exposure to ambient BTEX, both individually and as a mixture, with increased daily total, cardiovascular, and respiratory mortality.Our findings underscore the need for comprehensive air pollution mitigation policies, including stringent controls on BTEX emissions, to protect public health.Articlehttps://pubmed.ncbi.nlm.nih.gov/40972622https://www.thelancet.com/pdfs/journals/lanplh/PIIS2542-5196(25)00184-6.pdfhttps://doi.org/10.1016/j.lanplh.2025.10130610.1016/j.lanplh.2025.101306https://hdl.handle.net/20.500.15037/1165W4414257936enThe Lancet Planetary Health2542-51962025-09-012026-06-13T09:48:22Z2026-06-13T09:48:22Z |
| spellingShingle | Environmental science General partnership Environmental health Joint (building) Environmental planning Environmental protection Natural (archaeology) Foundation (evidence) Exposure assessment Environmental engineering Human health Xylene Heavy metals General partnership Joint (building) Natural (archaeology) Foundation (evidence) Exposure assessment Air Pollutants adverse effects Air Pollutants adverse effects Air Pollutants analysis Air Pollutants analysis Air Pollutants toxicity Air Pollutants toxicity Air Pollution adverse effects Air Pollution adverse effects Benzene adverse effects Benzene adverse effects Benzene analysis Benzene analysis Benzene toxicity Benzene toxicity Benzene Derivatives adverse effects Benzene Derivatives adverse effects Benzene Derivatives analysis Benzene Derivatives analysis Benzene Derivatives toxicity Benzene Derivatives toxicity Cardiovascular Diseases mortality Cardiovascular Diseases mortality Environmental Exposure adverse effects Environmental Exposure adverse effects Humans Humans Mortality Mortality Respiratory Tract Diseases chemically induced Respiratory Tract Diseases chemically induced Respiratory Tract Diseases mortality Respiratory Tract Diseases mortality Toluene adverse effects Toluene adverse effects Toluene analysis Toluene analysis Toluene toxicity Toluene toxicity Xylenes adverse effects Xylenes adverse effects Xylenes analysis Xylenes analysis Xylenes toxicity Xylenes toxicity Physical Sciences Environmental Science Health, Toxicology and Mutagenesis Indoor Air Quality and Microbial Exposure Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Carcinogens and Genotoxicity Assessment Physical Sciences Environmental Science Health, Toxicology and Mutagenesis Air Quality and Health Impacts Lu Zhou Xiong Ying Francesco Sera Ana Maria Vicedo-Cabrera Rosana Abrutzky Yuming Guo Shilu Tong Micheline de Sousa Zanotti Stagliorio Coêlho Paulo Hilario Nascimento Saldiva Éric Lavigne Patricia Matus Correa Nicolás Valdés Ortega Samuel Osorio Dominic Royé Jan Kyselý Hans Orru Marek Maasikmets Jouni J. K. Jaakkola Niilo Ryti Mathilde Pascal Veronika Huber Susanne Breitner-Busch Alexandra Schneider Klea Katsouyanni Evangelia Samoli Alireza Entezari Fatemeh Mayvaneh Patrick Goodman Ariana Zeka Raanan Raz Matteo Scortichini Massimo Stafoggia Yasushi Honda Masahiro Hashizume Chris Fook Sheng Ng Barrak Alahmad Magali Hurtado‐Díaz Eunice Elizabeth Félix Arellano Ala Overcenco Jochem O. Klompmaker Shilpa Rao Gabriel Carrasco‐Escobar Xerxes Seposo Paul Lester Chua Susana Pereira Silva Joana Madureira Iulian‐Horia Holobâcă Noah Scovronick Rebecca M. Garland Ho Kim Whanhee Lee Aurelio Tobı́as Carmen Íñiguez Bertil Forsberg Martina S. Ragettli Yue Leon Guo Shih‐Chun Pan Shanshan Li Pierre Masselot Valentina Colistro Michelle L. Bell Antonella Zanobetti Joel Schwartz Trần Ngọc Đăng Do Van Dung Antonio Gasparrini Yaoxian Huang Haidong Kan Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations |
| title | Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations |
| title_full | Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations |
| title_fullStr | Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations |
| title_full_unstemmed | Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations |
| title_short | Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations |
| title_sort | associations of ambient exposure to benzene toluene ethylbenzene and xylene with daily mortality a multicountry time series study in 757 global locations |
| topic | Environmental science General partnership Environmental health Joint (building) Environmental planning Environmental protection Natural (archaeology) Foundation (evidence) Exposure assessment Environmental engineering Human health Xylene Heavy metals General partnership Joint (building) Natural (archaeology) Foundation (evidence) Exposure assessment Air Pollutants adverse effects Air Pollutants adverse effects Air Pollutants analysis Air Pollutants analysis Air Pollutants toxicity Air Pollutants toxicity Air Pollution adverse effects Air Pollution adverse effects Benzene adverse effects Benzene adverse effects Benzene analysis Benzene analysis Benzene toxicity Benzene toxicity Benzene Derivatives adverse effects Benzene Derivatives adverse effects Benzene Derivatives analysis Benzene Derivatives analysis Benzene Derivatives toxicity Benzene Derivatives toxicity Cardiovascular Diseases mortality Cardiovascular Diseases mortality Environmental Exposure adverse effects Environmental Exposure adverse effects Humans Humans Mortality Mortality Respiratory Tract Diseases chemically induced Respiratory Tract Diseases chemically induced Respiratory Tract Diseases mortality Respiratory Tract Diseases mortality Toluene adverse effects Toluene adverse effects Toluene analysis Toluene analysis Toluene toxicity Toluene toxicity Xylenes adverse effects Xylenes adverse effects Xylenes analysis Xylenes analysis Xylenes toxicity Xylenes toxicity Physical Sciences Environmental Science Health, Toxicology and Mutagenesis Indoor Air Quality and Microbial Exposure Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Carcinogens and Genotoxicity Assessment Physical Sciences Environmental Science Health, Toxicology and Mutagenesis Air Quality and Health Impacts |
| topic_facet | Environmental science General partnership Environmental health Joint (building) Environmental planning Environmental protection Natural (archaeology) Foundation (evidence) Exposure assessment Environmental engineering Human health Xylene Heavy metals General partnership Joint (building) Natural (archaeology) Foundation (evidence) Exposure assessment Air Pollutants adverse effects Air Pollutants adverse effects Air Pollutants analysis Air Pollutants analysis Air Pollutants toxicity Air Pollutants toxicity Air Pollution adverse effects Air Pollution adverse effects Benzene adverse effects Benzene adverse effects Benzene analysis Benzene analysis Benzene toxicity Benzene toxicity Benzene Derivatives adverse effects Benzene Derivatives adverse effects Benzene Derivatives analysis Benzene Derivatives analysis Benzene Derivatives toxicity Benzene Derivatives toxicity Cardiovascular Diseases mortality Cardiovascular Diseases mortality Environmental Exposure adverse effects Environmental Exposure adverse effects Humans Humans Mortality Mortality Respiratory Tract Diseases chemically induced Respiratory Tract Diseases chemically induced Respiratory Tract Diseases mortality Respiratory Tract Diseases mortality Toluene adverse effects Toluene adverse effects Toluene analysis Toluene analysis Toluene toxicity Toluene toxicity Xylenes adverse effects Xylenes adverse effects Xylenes analysis Xylenes analysis Xylenes toxicity Xylenes toxicity Physical Sciences Environmental Science Health, Toxicology and Mutagenesis Indoor Air Quality and Microbial Exposure Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research Carcinogens and Genotoxicity Assessment Physical Sciences Environmental Science Health, Toxicology and Mutagenesis Air Quality and Health Impacts |
| url | https://pubmed.ncbi.nlm.nih.gov/40972622 https://www.thelancet.com/pdfs/journals/lanplh/PIIS2542-5196(25)00184-6.pdf https://doi.org/10.1016/j.lanplh.2025.101306 https://hdl.handle.net/20.500.15037/1165 |
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associationsofambientexposuretobenzenetolueneethylbenzeneandxylenewithdailymortalityamulticountrytimeseriesstudyin757globallocations AT haidongkan associationsofambientexposuretobenzenetolueneethylbenzeneandxylenewithdailymortalityamulticountrytimeseriesstudyin757globallocations |