Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations
Background The MDR1 gene presents several genetic polymorphisms with pharmacological implications. Therefore, the aim of the present study is to establish the genotype and allele frequencies of 3435C>T polymorphism of MDR1 gene into Peruvian populations (Coastal, Andean and Amazonian ecoregions),...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | Ver en el sistema de origen Enlace permanente (DOI o Handle) |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1881508816743301120 |
|---|---|
| author | Valencia Ayala, Edward Marcos Carbajal, Pool Barbosa Coelho, Eduardo Sandoval, Jose Sandoval Salazar‐Granara, Alberto |
| author_browse | Barbosa Coelho, Eduardo Marcos Carbajal, Pool Salazar‐Granara, Alberto Sandoval, Jose Sandoval Valencia Ayala, Edward |
| author_facet | Valencia Ayala, Edward Marcos Carbajal, Pool Barbosa Coelho, Eduardo Sandoval, Jose Sandoval Salazar‐Granara, Alberto |
| author_sort | Valencia Ayala, Edward |
| collection | Producción científica |
| description | Background The MDR1 gene presents several genetic polymorphisms with pharmacological implications. Therefore, the aim of the present study is to establish the genotype and allele frequencies of 3435C>T polymorphism of MDR1 gene into Peruvian populations (Coastal, Andean and Amazonian ecoregions), even considering the altitude (lowland <2500 m and highland >2500 m). Methods The polymorphism was analyzed by TaqMan genotyping assays in a group of 181 healthy unrelated Peruvian individuals. The comparison of genotype and allele frequencies of 3435C>T polymorphism was made with the Pearson test (X2), and, to calculate the genotype distributions, the Hardy-Weinberg equilibrium (HWE) was used. Results In all populations evaluated in this study, the genotype frequency distributions met HWE assumptions. The comparison between genotype and allele frequencies showed significant differences (p < 0.05), when the Andean, Coastal and Amazonian populations were compared. Also, significant differences (p < 0.05) were obtained when these populations were compared considering their altitudes. Likewise, in comparison with countries like USA, Finland, Nigeria and Kenya, the results showed significant differences (p < 0.05). Conclusions This investigation allowed us to establish the genotype and allele frequencies of 3435C>T polymorphism in different Peruvian populations, considering the geographic localization and even the altitude. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1152 |
| institution | UPeU |
| language | English |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/11522026-11-02T12:57:04ZGeographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populationsValencia Ayala, EdwardMarcos Carbajal, PoolBarbosa Coelho, EduardoSandoval, Jose SandovalSalazar‐Granara, AlbertoPharmacokineticsGenotypingGene polymorphismethnic populationBackground The MDR1 gene presents several genetic polymorphisms with pharmacological implications. Therefore, the aim of the present study is to establish the genotype and allele frequencies of 3435C>T polymorphism of MDR1 gene into Peruvian populations (Coastal, Andean and Amazonian ecoregions), even considering the altitude (lowland <2500 m and highland >2500 m). Methods The polymorphism was analyzed by TaqMan genotyping assays in a group of 181 healthy unrelated Peruvian individuals. The comparison of genotype and allele frequencies of 3435C>T polymorphism was made with the Pearson test (X2), and, to calculate the genotype distributions, the Hardy-Weinberg equilibrium (HWE) was used. Results In all populations evaluated in this study, the genotype frequency distributions met HWE assumptions. The comparison between genotype and allele frequencies showed significant differences (p < 0.05), when the Andean, Coastal and Amazonian populations were compared. Also, significant differences (p < 0.05) were obtained when these populations were compared considering their altitudes. Likewise, in comparison with countries like USA, Finland, Nigeria and Kenya, the results showed significant differences (p < 0.05). Conclusions This investigation allowed us to establish the genotype and allele frequencies of 3435C>T polymorphism in different Peruvian populations, considering the geographic localization and even the altitude.Articlehttps://pubmed.ncbi.nlm.nih.gov/3132300210.1515/dmpt-2018-0041https://hdl.handle.net/20.500.15037/115231323002W2962921946enDrug Metabolism and Personalized Therapy2363-89072363-89152019-07-192026-06-13T09:47:46Z2026-06-13T09:47:46Z |
| spellingShingle | Pharmacokinetics Genotyping Gene polymorphism ethnic population Valencia Ayala, Edward Marcos Carbajal, Pool Barbosa Coelho, Eduardo Sandoval, Jose Sandoval Salazar‐Granara, Alberto Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations |
| title | Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations |
| title_full | Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations |
| title_fullStr | Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations |
| title_full_unstemmed | Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations |
| title_short | Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations |
| title_sort | geographic distribution of the 3435c gt t polymorphism of the mdr1 gene in peruvian populations |
| topic | Pharmacokinetics Genotyping Gene polymorphism ethnic population |
| topic_facet | Pharmacokinetics Genotyping Gene polymorphism ethnic population |
| url | https://pubmed.ncbi.nlm.nih.gov/31323002 https://hdl.handle.net/20.500.15037/1152 |
| work_keys_str_mv | AT valenciaayalaedward geographicdistributionofthe3435cgttpolymorphismofthemdr1geneinperuvianpopulations AT marcoscarbajalpool geographicdistributionofthe3435cgttpolymorphismofthemdr1geneinperuvianpopulations AT barbosacoelhoeduardo geographicdistributionofthe3435cgttpolymorphismofthemdr1geneinperuvianpopulations AT sandovaljosesandoval geographicdistributionofthe3435cgttpolymorphismofthemdr1geneinperuvianpopulations AT salazargranaraalberto geographicdistributionofthe3435cgttpolymorphismofthemdr1geneinperuvianpopulations |