Comparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de Perú
Introduction: The appearance of multidrug-resistant and beta-lactamase producing enterobacteria in outpatient care facilities represent a public health problem in Perú. Objective: To compare the resistance profiles of uropathogenic Escherichia coli and to identify extended-spectrum beta-lactamase-pr...
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2020
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| author | Marcos Carbajal, Pool Galarza-Pérez, Marco Huancahuire Vega, Salomon Otiniano Trujillo, Miguel Angel Soto-Pastrana, Javier |
| author_browse | Galarza-Pérez, Marco Huancahuire Vega, Salomon Marcos Carbajal, Pool Otiniano Trujillo, Miguel Angel Soto-Pastrana, Javier |
| author_facet | Marcos Carbajal, Pool Galarza-Pérez, Marco Huancahuire Vega, Salomon Otiniano Trujillo, Miguel Angel Soto-Pastrana, Javier |
| author_sort | Marcos Carbajal, Pool |
| collection | Producción científica |
| description | Introduction: The appearance of multidrug-resistant and beta-lactamase producing enterobacteria in outpatient care facilities represent a public health problem in Perú. Objective: To compare the resistance profiles of uropathogenic Escherichia coli and to identify extended-spectrum beta-lactamase-producing phenotypes in three private health facilities located in the Peruvian coast, Andean and jungle regions. Materials and methods: We conducted a descriptive study on 98 urine samples from Lima (coast), Juliaca (Andean region) and Iquitos (jungle region) during 2016. We determined the antimicrobial susceptibility in 35 samples from Lima, 38 from Juliaca and 25 from Iquitos using eight antibiotic disks in samples from patients diagnosed with urinary infection. We also evaluated the production of extended-spectrum beta-lactamases with cefotaxime and ceftazidime disks and a combination of both with clavulanic acid on Mueller-Hinton agar. Results: We identified 18 resistance profiles ranging from those sensitive to others simultaneously resistant to seven antibiotics: 18.4% resistant to one and 54.0% to multiple antibiotics. We detected beta-lactamase production in 28.6% of the strains from the Puno region. Likewise, we observed a greater number of cases with resistance to ceftazidime, ceftriaxone, gentamicin, and trimethoprim-sulfamethoxazole in Puno’s health facility in patients within the 31 to 45 year age range. Conclusion: Resistance profiles varied according to the geographical location of the health facilities under study. Resistance to antibiotics was higher in the Andean region with 28.6% of strains producing extended-spectrum beta-lactamases. |
| format | Article |
| fuente_str | CRIS |
| fuente_tipo_str_mv | CRIS|Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1149 |
| institution | UPeU |
| language | Spanish |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| record_format | dspace |
| spelling | oai:cris.upeu.edu.pe:20.500.15037/11492026-11-02T12:57:04ZComparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de PerúMarcos Carbajal, PoolGalarza-Pérez, MarcoHuancahuire Vega, SalomonOtiniano Trujillo, Miguel AngelSoto-Pastrana, JavierDrug resistanceEnterobacteriaceaeUrinary tract infectionsBeta-lactamasesPerúDisk Diffusion Antimicrobial TestsIntroduction: The appearance of multidrug-resistant and beta-lactamase producing enterobacteria in outpatient care facilities represent a public health problem in Perú. Objective: To compare the resistance profiles of uropathogenic Escherichia coli and to identify extended-spectrum beta-lactamase-producing phenotypes in three private health facilities located in the Peruvian coast, Andean and jungle regions. Materials and methods: We conducted a descriptive study on 98 urine samples from Lima (coast), Juliaca (Andean region) and Iquitos (jungle region) during 2016. We determined the antimicrobial susceptibility in 35 samples from Lima, 38 from Juliaca and 25 from Iquitos using eight antibiotic disks in samples from patients diagnosed with urinary infection. We also evaluated the production of extended-spectrum beta-lactamases with cefotaxime and ceftazidime disks and a combination of both with clavulanic acid on Mueller-Hinton agar. Results: We identified 18 resistance profiles ranging from those sensitive to others simultaneously resistant to seven antibiotics: 18.4% resistant to one and 54.0% to multiple antibiotics. We detected beta-lactamase production in 28.6% of the strains from the Puno region. Likewise, we observed a greater number of cases with resistance to ceftazidime, ceftriaxone, gentamicin, and trimethoprim-sulfamethoxazole in Puno’s health facility in patients within the 31 to 45 year age range. Conclusion: Resistance profiles varied according to the geographical location of the health facilities under study. Resistance to antibiotics was higher in the Andean region with 28.6% of strains producing extended-spectrum beta-lactamases.Articlehttps://pubmed.ncbi.nlm.nih.gov/32463616https://revistabiomedica.org/index.php/biomedica/article/download/4772/4404https://doi.org/10.7705/biomedica.4772PMC744910210.7705/biomedica.4772https://hdl.handle.net/20.500.15037/114932463616W3030544037esBiomédica0120-41572590-73792020-05-012026-06-13T09:47:41Z2026-06-13T09:47:41Z |
| spellingShingle | Drug resistance Enterobacteriaceae Urinary tract infections Beta-lactamases Perú Disk Diffusion Antimicrobial Tests Marcos Carbajal, Pool Galarza-Pérez, Marco Huancahuire Vega, Salomon Otiniano Trujillo, Miguel Angel Soto-Pastrana, Javier Comparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de Perú |
| title | Comparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de Perú |
| title_full | Comparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de Perú |
| title_fullStr | Comparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de Perú |
| title_full_unstemmed | Comparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de Perú |
| title_short | Comparación de los perfiles de resistencia antimicrobiana de Escherichia coli uropatógena e incidencia de la producción de betalactamasas de espectro extendido en tres establecimientos privados de salud de Perú |
| title_sort | comparacion de los perfiles de resistencia antimicrobiana de escherichia coli uropatogena e incidencia de la produccion de betalactamasas de espectro extendido en tres establecimientos privados de salud de peru |
| topic | Drug resistance Enterobacteriaceae Urinary tract infections Beta-lactamases Perú Disk Diffusion Antimicrobial Tests |
| topic_facet | Drug resistance Enterobacteriaceae Urinary tract infections Beta-lactamases Perú Disk Diffusion Antimicrobial Tests |
| url | https://pubmed.ncbi.nlm.nih.gov/32463616 https://revistabiomedica.org/index.php/biomedica/article/download/4772/4404 https://doi.org/10.7705/biomedica.4772 https://hdl.handle.net/20.500.15037/1149 |
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