Diversity and functionality of the gut microbiota in hypertensive patients from different regions of Peru
Introduction Arterial hypertension affects around 19.4% of Peruvians over 15 years old, constituting a major public health issue. Recent evidence highlights the gut microbiome’s role in regulating blood pressure through bioactive metabolites that influence inflammation and metabolism. This study aim...
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2025
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| author | Marcos Carbajal, Pool Villegas Suarez, Milagros Nicole Rafael ccama, Vasty Vanessa Otiniano Trujillo, Miguel Angel Huancahuire Vega, Salomon Chambi Quispe, Mario Salomon Luque Arapa, Alvaro Ruiz Panaifo, Manuel Diaz Rengifo, Pilar Elizabeth Sias Garay, Cinthia Esther Espinoza rojas, Ruben Tito, Raul Rohra benitez, Sonia Tapia Paniagua, Silvana |
| author_browse | Chambi Quispe, Mario Salomon Diaz Rengifo, Pilar Elizabeth Espinoza rojas, Ruben Huancahuire Vega, Salomon Luque Arapa, Alvaro Marcos Carbajal, Pool Otiniano Trujillo, Miguel Angel Rafael ccama, Vasty Vanessa Rohra benitez, Sonia Ruiz Panaifo, Manuel Sias Garay, Cinthia Esther Tapia Paniagua, Silvana Tito, Raul Villegas Suarez, Milagros Nicole |
| author_facet | Marcos Carbajal, Pool Villegas Suarez, Milagros Nicole Rafael ccama, Vasty Vanessa Otiniano Trujillo, Miguel Angel Huancahuire Vega, Salomon Chambi Quispe, Mario Salomon Luque Arapa, Alvaro Ruiz Panaifo, Manuel Diaz Rengifo, Pilar Elizabeth Sias Garay, Cinthia Esther Espinoza rojas, Ruben Tito, Raul Rohra benitez, Sonia Tapia Paniagua, Silvana |
| author_sort | Marcos Carbajal, Pool |
| collection | Producción científica |
| description | Introduction Arterial hypertension affects around 19.4% of Peruvians over 15 years old, constituting a major public health issue. Recent evidence highlights the gut microbiome’s role in regulating blood pressure through bioactive metabolites that influence inflammation and metabolism. This study aims to characterize the gut microbiota of hypertensive adults from three Peruvian regions, contributing to the understanding of microbial influences on hypertension. Objective To analyze the composition and functionality of the gut microbiota in hypertensive and normotensive adults from different Peruvian regions, considering age, body mass index (BMI), and geographical location. Methods An observational, cross-sectional, and analytical study was conducted with 84 adults (46 hypertensive and 38 normotensive) from nine regions of Peru. Fecal samples underwent metagenomic sequencing of the 16S rRNA gene (V3–V4 region). Alpha and beta diversity were evaluated using the Shannon index, UniFrac distances, and multivariate analyses. Microbial functional pathways were examined to identify potential metabolic differences between groups. Results The dominant phyla in all groups were Bacillota and Bacteroidota. At the genus level, Streptococcus was associated with hypertensive patients with BMI ≥25, while Alistipes appeared only in normotensive individuals with BMI <25. Alpha diversity was greater in hypertensive participants under 50 years and with BMI <25, while lower diversity was seen in normotensive adults over 50 and with BMI ≥25. Beta diversity showed partial clustering by hypertension and age, with regional overlap. Functional profiles were similar among groups, mainly involving carbohydrate, amino acid, and lipid metabolism, though BMI and age modulated these patterns. Conclusions Gut microbiota composition and diversity in Peruvian adults are influenced by hypertension, age, BMI, and region. Despite comparable functional profiles, environmental and nutritional factors may have a stronger impact than hypertension alone, offering insight for region-specific prevention and treatment strategies. |
| format | Article |
| id | oai:cris.upeu.edu.pe:20.500.15037/1127 |
| institution | UPeU |
| language | English |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/11272026-11-02T12:57:04ZDiversity and functionality of the gut microbiota in hypertensive patients from different regions of PeruMarcos Carbajal, PoolVillegas Suarez, Milagros NicoleRafael ccama, Vasty VanessaOtiniano Trujillo, Miguel AngelHuancahuire Vega, SalomonChambi Quispe, Mario SalomonLuque Arapa, AlvaroRuiz Panaifo, ManuelDiaz Rengifo, Pilar ElizabethSias Garay, Cinthia EstherEspinoza rojas, RubenTito, RaulRohra benitez, SoniaTapia Paniagua, SilvanaHigh blood pressuregut microbiotamicrobiome diversityPeruIntroduction Arterial hypertension affects around 19.4% of Peruvians over 15 years old, constituting a major public health issue. Recent evidence highlights the gut microbiome’s role in regulating blood pressure through bioactive metabolites that influence inflammation and metabolism. This study aims to characterize the gut microbiota of hypertensive adults from three Peruvian regions, contributing to the understanding of microbial influences on hypertension. Objective To analyze the composition and functionality of the gut microbiota in hypertensive and normotensive adults from different Peruvian regions, considering age, body mass index (BMI), and geographical location. Methods An observational, cross-sectional, and analytical study was conducted with 84 adults (46 hypertensive and 38 normotensive) from nine regions of Peru. Fecal samples underwent metagenomic sequencing of the 16S rRNA gene (V3–V4 region). Alpha and beta diversity were evaluated using the Shannon index, UniFrac distances, and multivariate analyses. Microbial functional pathways were examined to identify potential metabolic differences between groups. Results The dominant phyla in all groups were Bacillota and Bacteroidota. At the genus level, Streptococcus was associated with hypertensive patients with BMI ≥25, while Alistipes appeared only in normotensive individuals with BMI <25. Alpha diversity was greater in hypertensive participants under 50 years and with BMI <25, while lower diversity was seen in normotensive adults over 50 and with BMI ≥25. Beta diversity showed partial clustering by hypertension and age, with regional overlap. Functional profiles were similar among groups, mainly involving carbohydrate, amino acid, and lipid metabolism, though BMI and age modulated these patterns. Conclusions Gut microbiota composition and diversity in Peruvian adults are influenced by hypertension, age, BMI, and region. Despite comparable functional profiles, environmental and nutritional factors may have a stronger impact than hypertension alone, offering insight for region-specific prevention and treatment strategies.Articlehttps://f1000research.com/articles/14-1401/pdfhttps://doi.org/10.12688/f1000research.170893.110.12688/f1000research.170893.1https://hdl.handle.net/20.500.15037/1127W7162531738enF1000ResearchAnálisis del microbioma en pacientes con enfermedades metabólicas en el Perú: Un enfoque multidisciplinario para la mejora de la Salud pública2046-1402Análisis del microbioma en pacientes con enfermedades metabólicas en el Perú: Un enfoque multidisciplinario para la mejora de la Salud públicaPICB-2024-1-000000022025-12-152026-06-13T09:47:03Z2026-06-13T09:47:03Z |
| spellingShingle | High blood pressure gut microbiota microbiome diversity Peru Marcos Carbajal, Pool Villegas Suarez, Milagros Nicole Rafael ccama, Vasty Vanessa Otiniano Trujillo, Miguel Angel Huancahuire Vega, Salomon Chambi Quispe, Mario Salomon Luque Arapa, Alvaro Ruiz Panaifo, Manuel Diaz Rengifo, Pilar Elizabeth Sias Garay, Cinthia Esther Espinoza rojas, Ruben Tito, Raul Rohra benitez, Sonia Tapia Paniagua, Silvana Diversity and functionality of the gut microbiota in hypertensive patients from different regions of Peru |
| title | Diversity and functionality of the gut microbiota in hypertensive patients from different regions of Peru |
| title_full | Diversity and functionality of the gut microbiota in hypertensive patients from different regions of Peru |
| title_fullStr | Diversity and functionality of the gut microbiota in hypertensive patients from different regions of Peru |
| title_full_unstemmed | Diversity and functionality of the gut microbiota in hypertensive patients from different regions of Peru |
| title_short | Diversity and functionality of the gut microbiota in hypertensive patients from different regions of Peru |
| title_sort | diversity and functionality of the gut microbiota in hypertensive patients from different regions of peru |
| topic | High blood pressure gut microbiota microbiome diversity Peru |
| topic_facet | High blood pressure gut microbiota microbiome diversity Peru |
| url | https://f1000research.com/articles/14-1401/pdf https://doi.org/10.12688/f1000research.170893.1 https://hdl.handle.net/20.500.15037/1127 |
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