A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome?
Rationale: The long-term consequences of COVID-19 infection on hospitalized patients remains unknown. We sought to conduct a systematic review to summarize what is known about long term sequelae among patients who were hospitalized for severe COVID-19 pneumonia. Methods: We conducted a search in MED...
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2021
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| author | A.N. Soriano-Moreno David R. Soriano‐Moreno Niels Pacheco‐Barrios Aimé Lescano William Checkley |
| author_browse | A.N. Soriano-Moreno Aimé Lescano David R. Soriano‐Moreno Niels Pacheco‐Barrios William Checkley |
| author_facet | A.N. Soriano-Moreno David R. Soriano‐Moreno Niels Pacheco‐Barrios Aimé Lescano William Checkley |
| author_sort | A.N. Soriano-Moreno |
| collection | Producción científica |
| description | Rationale: The long-term consequences of COVID-19 infection on hospitalized patients remains unknown. We sought to conduct a systematic review to summarize what is known about long term sequelae among patients who were hospitalized for severe COVID-19 pneumonia. Methods: We conducted a search in MEDLINE and MedRxiv through December 15, 2020, using the search terms: “COVID-19”, “Constitutional symptoms”, “COVID- 19 Sequelae”, “Long-term COVID-19” and “Respiratory symptoms.” Articles were evaluated independently by two authors. We then extracted to perform a quantitative synthesis of available evidence and scored studies for quality using the NIH quality assessment Tool for Observational Cohort and Cross-Sectional Studies. Results: We identified 12 studies: nine published articles and three preprints. We obtained data for 4693 patients: 11 studies included hospitalized patients, 8 included ICU patients and 5 included outpatients. Follow-up time ranged from 16 days to 122 days post-hospitalization. The pooled prevalence of persistent constitutional and respiratory symptoms was: (45.6%), dyspnea (35.5%), cough (26.4%), joint pain (26.8%), myalgia (23.3%), headache (22.2%), and chest pain (20.5%). Heterogeneity across studies was high (I2>90%). Chinese studies reported a lower frequency of persistent symptoms compared with studies carried out in Western countries (e.g., France, Italy, USA, UK). There were no significant differences in long-term sequelae between ICU and non-ICU patients. Conclusion: The prevalence of persistent constitutional and respiratory symptoms in patients infected with COVID-19 is high. Addressing the burden of symptoms that reduce the quality of life is critical in COVID-19 patients. |
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| id | oai:cris.upeu.edu.pe:20.500.15037/1055 |
| institution | UPeU |
| language | English |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
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| spelling | oai:cris.upeu.edu.pe:20.500.15037/10552026-10-30T16:15:08ZA Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome?A.N. Soriano-MorenoDavid R. Soriano‐MorenoNiels Pacheco‐BarriosAimé LescanoWilliam CheckleyCoronavirus disease 2019 (COVID-19)Medicine2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BetacoronavirusPandemicMEDLINEIntensive care medicineVirologyInternal medicineDiseaseOutbreakLawPolitical scienceInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)Medicine2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BetacoronavirusPandemicMEDLINEIntensive care medicineVirologyInternal medicineDiseaseOutbreakLawHealth Sciences Medicine Neurology Long-Term Effects of COVID-19Health Sciences Medicine Psychiatry and Mental health Psychosomatic Disorders and Their TreatmentsLife Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and EffectsRationale: The long-term consequences of COVID-19 infection on hospitalized patients remains unknown. We sought to conduct a systematic review to summarize what is known about long term sequelae among patients who were hospitalized for severe COVID-19 pneumonia. Methods: We conducted a search in MEDLINE and MedRxiv through December 15, 2020, using the search terms: “COVID-19”, “Constitutional symptoms”, “COVID- 19 Sequelae”, “Long-term COVID-19” and “Respiratory symptoms.” Articles were evaluated independently by two authors. We then extracted to perform a quantitative synthesis of available evidence and scored studies for quality using the NIH quality assessment Tool for Observational Cohort and Cross-Sectional Studies. Results: We identified 12 studies: nine published articles and three preprints. We obtained data for 4693 patients: 11 studies included hospitalized patients, 8 included ICU patients and 5 included outpatients. Follow-up time ranged from 16 days to 122 days post-hospitalization. The pooled prevalence of persistent constitutional and respiratory symptoms was: (45.6%), dyspnea (35.5%), cough (26.4%), joint pain (26.8%), myalgia (23.3%), headache (22.2%), and chest pain (20.5%). Heterogeneity across studies was high (I2>90%). Chinese studies reported a lower frequency of persistent symptoms compared with studies carried out in Western countries (e.g., France, Italy, USA, UK). There were no significant differences in long-term sequelae between ICU and non-ICU patients. Conclusion: The prevalence of persistent constitutional and respiratory symptoms in patients infected with COVID-19 is high. Addressing the burden of symptoms that reduce the quality of life is critical in COVID-19 patients.Other10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3795https://hdl.handle.net/20.500.15037/1055W3174509440en2021-05-012026-06-13T09:44:51Z2026-06-13T09:44:51Z |
| spellingShingle | Coronavirus disease 2019 (COVID-19) Medicine 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Betacoronavirus Pandemic MEDLINE Intensive care medicine Virology Internal medicine Disease Outbreak Law Political science Infectious disease (medical specialty) Coronavirus disease 2019 (COVID-19) Medicine 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Betacoronavirus Pandemic MEDLINE Intensive care medicine Virology Internal medicine Disease Outbreak Law Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Health Sciences Medicine Psychiatry and Mental health Psychosomatic Disorders and Their Treatments Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and Effects A.N. Soriano-Moreno David R. Soriano‐Moreno Niels Pacheco‐Barrios Aimé Lescano William Checkley A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome? |
| title | A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome? |
| title_full | A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome? |
| title_fullStr | A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome? |
| title_full_unstemmed | A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome? |
| title_short | A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome? |
| title_sort | systematic review of the frequency of persistent constitutional and respiratory symptoms related to covid 19 a new long covid syndrome |
| topic | Coronavirus disease 2019 (COVID-19) Medicine 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Betacoronavirus Pandemic MEDLINE Intensive care medicine Virology Internal medicine Disease Outbreak Law Political science Infectious disease (medical specialty) Coronavirus disease 2019 (COVID-19) Medicine 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Betacoronavirus Pandemic MEDLINE Intensive care medicine Virology Internal medicine Disease Outbreak Law Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Health Sciences Medicine Psychiatry and Mental health Psychosomatic Disorders and Their Treatments Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and Effects |
| topic_facet | Coronavirus disease 2019 (COVID-19) Medicine 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Betacoronavirus Pandemic MEDLINE Intensive care medicine Virology Internal medicine Disease Outbreak Law Political science Infectious disease (medical specialty) Coronavirus disease 2019 (COVID-19) Medicine 2019-20 coronavirus outbreak Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Betacoronavirus Pandemic MEDLINE Intensive care medicine Virology Internal medicine Disease Outbreak Law Health Sciences Medicine Neurology Long-Term Effects of COVID-19 Health Sciences Medicine Psychiatry and Mental health Psychosomatic Disorders and Their Treatments Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology Pharmacological Receptor Mechanisms and Effects |
| url | https://hdl.handle.net/20.500.15037/1055 |
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