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Associations of ambient exposure to benzene, toluene, ethylbenzene, and xylene with daily mortality: a multicountry time-series study in 757 global locations por Lu Zhou, Xiong Ying, Francesco Sera, Ana Maria Vicedo-Cabrera, Rosana Abrutzky, Yuming Guo, Shilu Tong, Micheline de Sousa Zanotti Stagliorio Coêlho, Paulo Hilario Nascimento Saldiva, Éric Lavigne, Patricia Matus Correa, Nicolás Valdés Ortega, Samuel Osorio, Dominic Royé, Jan Kyselý, Hans Orru, Marek Maasikmets, Jouni J. K. Jaakkola, Niilo Ryti, Mathilde Pascal, Veronika Huber, Susanne Breitner-Busch, Alexandra Schneider, Klea Katsouyanni, Evangelia Samoli, Alireza Entezari, Fatemeh Mayvaneh, Patrick Goodman, Ariana Zeka, Raanan Raz, Matteo Scortichini, Massimo Stafoggia, Yasushi Honda, Masahiro Hashizume, Chris Fook Sheng Ng, Barrak Alahmad, Magali Hurtado‐Díaz, Eunice Elizabeth Félix Arellano, Ala Overcenco, Jochem O. Klompmaker, Shilpa Rao, Gabriel Carrasco‐Escobar, Xerxes Seposo, Paul Lester Chua, Susana Pereira Silva, Joana Madureira, Iulian‐Horia Holobâcă, Noah Scovronick, Rebecca M. Garland, Ho Kim, Whanhee Lee, Aurelio Tobı́as, Carmen Íñiguez, Bertil Forsberg, Martina S. Ragettli, Yue Leon Guo, Shih‐Chun Pan, Shanshan Li, Pierre Masselot, Valentina Colistro, Michelle L. Bell, Antonella Zanobetti, Joel Schwartz, Trần Ngọc Đăng, Do Van Dung, Antonio Gasparrini, Yaoxian Huang, Haidong Kan

“…Data on individual chemicals (ie, benzene, toluene, xylenes [summation of ethylbenzene, m-xylene, p-xylene, and o-xylene]) and the aggregate mixture (ie, BTEX) were estimated using a chemistry-climate model.We examined the short-term associations of each individual chemical as well as the BTEX mixture with daily total, cardiovascular, and respiratory mortality in a multicountry framework.Using a two-stage time-series design, we first applied generalised additive models with a quasi-Poisson distribution to obtain location-specific associations, which were subsequently pooled using random-effects meta-analysis.Two-pollutant models were used to assess the independent effects of BTEX after adjusting for co-pollutants (PM 25 , PM 10 , nitrogen dioxide, sulphur dioxide, ozone, and carbon monoxide).Additionally, we assessed the overall exposure-response curves with spline terms.Findings An IQR increment of BTEX concentration on lag 0-2 days (3-day moving average of the present day and the previous 2 days) was associated with increases of 057% (95% CI 049-065), 042% (030-054), and 068% (050-086) in total, cardiovascular, and respiratory mortality, respectively.The corresponding effect estimates for an IQR increment in individual chemicals (benzene, toluene, and xylenes) were 038-061%, 044-070%, and 041-065%, respectively.The associations remained significant after adjusting for co-pollutants, with a general decline in magnitude, except for a slight increase after adjustment for ozone.The shape of the exposureresponse curves for all pollutants and causes of death was almost linear, with steeper slopes at low concentrations and no discernible thresholds.Interpretation This global study provides novel evidence linking short-term exposure to ambient BTEX, both individually and as a mixture, with increased daily total, cardiovascular, and respiratory mortality.Our findings underscore the need for comprehensive air pollution mitigation policies, including stringent controls on BTEX emissions, to protect public health.…”
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Temperature frequency and mortality: Assessing adaptation to local temperature por Yao Wu, Bo Wen, Antonio Gasparrini, Ben Armstrong, Francesco Sera, Éric Lavigne, Shanshan Li, Yuming Guo, Ala Overcenco, Aleš Urban, Alexandra Schneider, Alireza Entezari, Ana María Vicedo-Cabrera, Antonella Zanobetti, Antonis Analitis, Ariana Zeka, Aurelio Tobı́as, Baltazar Nunes, Barrak Alahmad, Bertil Forsberg, Carmen Íñiguez, Caroline Ameling, César De la Cruz Valencia, Danny Houthuijs, Do Van Dung, Dominic Royé, Ene Indermitte, Fatemeh Mayvaneh, Fiorella Acquaotta, Francesca de’Donato, Gabriel Carrasco‐Escobar, Haidong Kan, Hanne Krage Carlsen, Hans Orru, Ho Kim, Iulian‐Horia Holobâcă, Jan Kyselý, Joana Madureira, Joel Schwartz, Jouni J. K. Jaakkola, Klea Katsouyanni, Magali Hurtado‐Díaz, Martina S. Ragettli, Masahiro Hashizume, Mathilde Pascal, Micheline de Sousa Zanotti Stagliorio Coêlho, Nicolás Valdés Ortega, Niilo Ryti, Noah Scovronick, Paola Michelozzi, Patricia Matus Correa, Patrick Goodman, Paulo Hilário Nascimento Saldiva, Raanan Raz, Rosana Abrutzky, Samuel Osorio, Shih‐Chun Pan, Shilpa Rao, Shilu Tong, Souzana Achilleos, Trần Ngọc Đăng, Valentina Colistro, Veronika Huber, Whanhee Lee, Xerxes Seposo, Yasushi Honda, Yoonhee Kim, Yue Leon Guo, Shanshan Li, Yuming Guo

“…We collected daily time-series data on mortality and temperature from 757 locations in 47 countries/regions during 1979-2020. We used a two-stage time series design to assess the association between temperature frequency and all-cause mortality. …”
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