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  1. 43601
  2. 43602

    Diversity and dissemination of viruses in pathogenic protozoa por Senne Heeren, Ilse Maes, Mandy Sanders, Lon‐Fye Lye, Vanessa Adaui, Jorge Arévalo, Alejandro Llanos‐Cuentas, Lineth García, Philippe Lemey, Stephen M. Beverley, James A. Cotton, Jean‐Claude Dujardin, Frederik Van den Broeck

    Publicado 2023
    “…In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. …”
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  3. 43603
  4. 43604

    Unveiling drug-tolerant and persister-like cells in Leishmania braziliensis lines derived from patients with cutaneous leishmaniasis por Marlene Jara, Jorge Arévalo, Alejandro Llanos‐Cuentas, Frederik Van den Broeck, Malgorzata A. Domagalska, Jean‐Claude Dujardin

    Publicado 2023
    “…Results and discussion We demonstrated in vitro that a variable proportion of cells remained viable, showing all the criteria of DT and not of DR: i) signatures of quiescence, under drug pressure: reduced proliferation and significant decrease of rDNA transcription; ii) reversibility of the phenotype: return to low IC 50 after removal of drug pressure; and iii) absence of significant genetic differences between exposed and unexposed lineages of each strain and absence of reported markers of DR. …”
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  5. 43605

    Parasite hybridization promotes spreading of endosymbiotic viruses por Senne Heeren, Ilse Maes, Mandy Sanders, Lon‐Fye Lye, Jorge Arévalo, Alejandro Llanos‐Cuentas, Lineth García, Philippe Lemey, Stephen M. Beverley, James A. Cotton, Jean‐Claude Dujardin, Frederik Van den Broeck

    Publicado 2023
    “…In pathogenic protozoa, the presence of endosymbiotic viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis parasites and their endosymbiotic Leishmania RNA virus. …”
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  6. 43606
  7. 43607

    Novel CRISPR-based detection of Leishmania species por Eva Dueñas, Jose A. Nakamoto, Luis Cabrera-Sosa, Percy Huaihua, María Cruz, Jorge Arévalo, Pohl Milón, Vanessa Adaui

    Publicado 2022
    “…Our CRISPR-based assays were capable of detecting down to 5 × 10 −2 (kDNA) or 5 × 10 0 (18S rDNA) parasite genome equivalents/reaction with PCR preamplification. …”
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  8. 43608
  9. 43609
  10. 43610
  11. 43611
  12. 43612
  13. 43613

    Risk factors for cutaneous leishmaniasis in a high-altitude forest region of Peru por Justin T. Lana, Andrés Mallipudi, Ernesto Ortiz, Heriberto Arévalo Ramírez, Alejandro Llanos‐Cuentas, William Pan

    Publicado 2021
    “…Children and working aged women made up 58.6% of the cases. Our final model suggests that the odds of sleeping in or very near an agricultural field were five times greater in cases than controls (p = 0.025). …”
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  14. 43614
  15. 43615
  16. 43616
  17. 43617
  18. 43618
  19. 43619
  20. 43620